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CD11c Antibody – Hamster Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690274

Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CD11c, Monoclonal Antibody
Full Product Name
Hamster Anti-Mouse CD11c
Product Gene Name
Product Synonym Names
ITGAX; CD11C; SLEB6
Clonality
Monoclonal
Isotype
IgG
Clone Number
(MAB0806)
Host
Hamster
Species Reactivity
Mouse
Form/Format
Lyophilized
Purity/Purification
Protein A/G affinity chromatography
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity. Avoid freeze/thaw cycles.
Chromosome Location
Chromosome: 7; NC_000073.6 (128129529..128150657). Location: 7 F3; 7
3D Structure
ModBase 3D Structure for Q9QXH4
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
Reconstitution buffer
PBS (sterile)
Preparation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from an armenian hamster) immunized with mouse lymphcytes.
Antigen
Mouse lymphocytes
Remarks
This antibody was selected for its ability to detectmouse CD11c.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-CD11c antibody
Immunohistochemistry (IHC) - Paraffin, Flow Cytometry (FC/FACS), Immunoprecipitation (IP)
Application Notes for anti-CD11c antibody
FC: 1:100-1000
IP: 1:100
IHC (Paraffin): 1: 25-100

Optimal dilutions should be determined by each laboratory for each applications.

Testing Data of anti-CD11c antibody

Hamster Anti-CD11c Monoclonal Antibody – Cat# MBS690274

Other Notes

Small volumes of anti-CD11c antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD11c purchase

MBS690274 is an antibody targeting CD11c. Also known as Hamster Anti-Mouse CD11c. Reactive in Mouse. Host: Hamster.

Additional Details

NCBI/Uniprot data below describe general gene information for CD11c. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
integrin alpha-X
NCBI Official Synonym Full Names
integrin alpha X
NCBI Official Symbol
Itgax
NCBI Official Synonym Symbols
Cr4; N418; Cd11c; AI449405
UniProt Protein Name
Integrin alpha-X
UniProt Synonym Protein Names
CD11 antigen-like family member C; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95
Protein Family
UniProt Gene Name
Itgax
UniProt Entry Name
ITAX_MOUSE
NCBI Protein Information
integrin alpha-X; integrin aX; complement receptor 4; CD11C (p150) alpha polypeptide; CD11 antigen-like family member C; leukocyte adhesion receptor p150,95; leukocyte adhesion glycoprotein p150,95 alpha chain

UniProt Comments for CD11c

Function: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis

By similarity.

Subunit structure: Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein

By similarity.

Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similarities: Belongs to the integrin alpha chain family.Contains 7 FG-GAP repeats.Contains 1 VWFA domain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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