Mouse Anti-GZMH Monoclonal Antibody – Cat# MBS690291

Granzyme H (GZMH) Antibody – Mouse Monoclonal

Name: GZMH Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690291
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690291

The Granzyme family of proteins belong to the larger peptidase S1 family. Granzyme A and granzyme B are serine proteases that facilitate apoptotic signaling in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Within the granules of activated CTLs,… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Granzyme H (GZMH), Monoclonal Antibody

Full Product Name

Mouse Anti-Human Granzyme H

Product Gene Name

anti-GZMH antibody

Product Synonym Names

GZMH; CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2

Clonality

Monoclonal

Isotype

IgG2

Clone Number

(10A39)

Host

Mouse

Species Reactivity

Human

Form/Format

Lyophilized

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

27,315 Da

Chromosome Location

Chromosome: 14; NC_000014.9 (24606480..24609720, complement). Location: 14q11.2

OMIM

116831

3D Structure

ModBase 3D Structure for P20718

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Granzyme H.

Reconstitution

Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-GZMH antibody

Western Blot (WB)

Other Notes

Small volumes of anti-GZMH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GZMH purchase

MBS690291 is an antibody targeting GZMH. Also known as Mouse Anti-Human Granzyme H. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for GZMH. It may not necessarily be applicable to this product.

NCBI GI #

399124767

NCBI GeneID

2999

NCBI Accession #

NP_001257710.1

UniProt Primary Accession #

P20718

UniProt Secondary Accession #

Q6XGZ0; Q6XGZ1; G3V2C5

UniProt Related Accession #

P20718

GenBank Nucleotide #

NM_001270781.1

NCBI Official Full Name

granzyme H isoform 3

NCBI Official Synonym Full Names

granzyme H (cathepsin G-like 2, protein h-CCPX)

NCBI Official Symbol

GZMH

NCBI Official Synonym Symbols

CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2

UniProt Protein Name

Granzyme H

UniProt Synonym Protein Names

CCP-X; Cathepsin G-like 2; CTSGL2; Cytotoxic T-lymphocyte proteinase; Cytotoxic serine protease C

Protein Family

Granzyme

UniProt Gene Name

GZMH

UniProt Synonym Gene Names

CGL2; CTSGL2; CTSGL2; CSP-C

UniProt Entry Name

GRAH_HUMAN

NCBI Protein Information

granzyme H; cytotoxin serine protease-C; cytotoxic T-lymphocyte proteinase; cytotoxic T-lymphocyte-associated serine esterase 1

NCBI Summary for GZMH

The protein encoded by this gene is a member of the granzyme family. Members of this family are highly conserved serine proteases that eliminate transformed cells and virus-infected cells. This protein, which has chymotrypsin-like activity, has a preference for bulky aromatic amino acids at the P1 position and for acidic residues at the P3' and P4' positions. This protein is reported to be constitutively expressed in NK cells and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

UniProt Comments for GZMH

Function: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. Ref.8 Ref.9

Enzyme regulation: Inhibited by SERPINB1. Ref.9

Subcellular location: Cytoplasmic granule. Note: Cytoplasmic granules of cytolytic T-lymphocytes.

Tissue specificity: Constituvely expressed in NK cells. Ref.9

Sequence similarities: Belongs to the peptidase S1 family. Granzyme subfamily.Contains 1 peptidase S1 domain.

Research Articles on GZMH

1. Granzyme H did directly process DFF45, potentially leading to DNA damage.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GZMH antibody

Reference Product	PubMed Publications
GZMB antibody	>22 publications with GZMH and GZMB
PRF1 antibody	>7 publications with GZMH and PRF1
GZMA antibody	>2 publications with GZMH and GZMA
CCL5 antibody	>1 publications with GZMH and CCL5
GZMK antibody	>1 publications with GZMH and GZMK

Pathways associated with anti-GZMH antibody

Products by Pathway	Pathway Diagram
Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies	Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
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Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies	Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram

Diseases associated with anti-GZMH antibody

Disease Name	Pubmed Publications
Death Antibodies	>7 publications with GZMH and Death
Neoplasms Antibodies	>3 publications with GZMH and Neoplasms
Lymphatic Diseases Antibodies	>3 publications with GZMH and Lymphatic Diseases
Breast Neoplasms Antibodies	>1 publications with GZMH and Breast Neoplasms
Inflammation Antibodies	>1 publications with GZMH and Inflammation

Organs/Tissues associated with anti-GZMH antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>15 publications with GZMH and Blood