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GAS-6 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690301

Gas6 (Growth Arrest Specific 6) is one of six structurally unrelated proteins that are secreted by a wide variety of cell types in response to growth arrest. Gas6 and the structurally related Protein S are vitamin K-dependent and have an extensively… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
Gas-6, Monoclonal Antibody
Full Product Name
Rat Anti-Mouse Gas-6
Product Gene Name
anti-Gas-6 antibody
Product Synonym Names
Anti-mouse Gas6 (#6J2)
Clonality
Monoclonal
Isotype
IgG2
Clone Number
(6J2)
Host
Rat
Species Reactivity
Mouse
Form/Format
The IgG fraction of culture supernatant was purified by Protein A/G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS). Lyophilized samples are stable for 2 years from date of receipt when stored at
Purity/Purification
Protein A/G affinity chromatography
Specificity
This antibody detects mouse Gas6 in Western blotting.
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
Molecular Weight
74,610 Da
Chromosome Location
Chromosome: 8; NC_000074.6 (13465374..13494535, complement). Location: 8 A1.1; 8 6.06 cM
3D Structure
ModBase 3D Structure for Q61592
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant Gas6. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-Gas-6 antibody
Western Blot (WB)
Application Notes for anti-Gas-6 antibody
1. Western blot: Yes (1:500-1000)

Other Notes

Small volumes of anti-Gas-6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Gas-6 purchase

MBS690301 is an antibody targeting Gas-6. Also known as Rat Anti-Mouse Gas-6. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for Gas-6. It may not necessarily be applicable to this product.

NCBI GI #
145301603
NCBI GeneID
14456
NCBI Accession #
NP_062394.2
UniProt Primary Accession #
Q61592
UniProt Secondary Accession #
Q99K57
UniProt Related Accession #
Q61592
GenBank Nucleotide #
NM_019521.2
NCBI Official Full Name
growth arrest-specific protein 6
NCBI Official Synonym Full Names
growth arrest specific 6
NCBI Official Symbol
Gas6
NCBI Official Synonym Symbols
Gas-6
UniProt Protein Name
Growth arrest-specific protein 6
UniProt Synonym Protein Names
AXL receptor tyrosine kinase ligand
Protein Family
Growth arrest-specific protein
UniProt Gene Name
Gas6
UniProt Synonym Gene Names
GAS-6
UniProt Entry Name
GAS6_MOUSE
NCBI Protein Information
growth arrest-specific protein 6; GAS 6; AXL receptor tyrosine kinase ligand

UniProt Comments for Gas-6

Function: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Ref.3

Subunit structure: Heterodimer and heterotetramer with AXL.

Subcellular location: Secreted

By similarity.

Post-translational modification: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium

By similarity.

Miscellaneous: GAS6 deficient mice show protection against thrombosis, but no spontaneous bleeding.

Sequence similarities: Contains 4 EGF-like domains.Contains 1 Gla (gamma-carboxy-glutamate) domain.Contains 2 laminin G-like domains.
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Research Articles on Gas-6

1. Gas6 deficiency enhanced mouse colitis-associated tumorigenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Gas-6 antibody

 Reference Product  PubMed Publications
 Axl antibody  >232 publications with Gas-6 and Axl
 Mertk antibody  >60 publications with Gas-6 and Mertk
 Tgfb1 antibody  >3 publications with Gas-6 and Tgfb1
 Serpine1 antibody  >2 publications with Gas-6 and Serpine1
 Fn1 antibody  >1 publications with Gas-6 and Fn1
 Furin antibody  >1 publications with Gas-6 and Furin

Pathways associated with anti-Gas-6 antibody

 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Gamma-carboxylation Of Protein Precursors Pathway antibodies  Gamma-carboxylation Of Protein Precursors Pathway Diagram
 Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies  Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 PTM: Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway antibodies  PTM: Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Removal Of Aminoterminal Propeptides From Gamma-carboxylated Proteins Pathway antibodies  Removal Of Aminoterminal Propeptides From Gamma-carboxylated Proteins Pathway Diagram

Diseases associated with anti-Gas-6 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >72 publications with Gas-6 and Neoplasms
 Inflammation Antibodies  >50 publications with Gas-6 and Inflammation
 Cardiovascular Diseases Antibodies  >48 publications with Gas-6 and Cardiovascular Diseases
 Necrosis Antibodies  >29 publications with Gas-6 and Necrosis
 Disease Models, Animal Antibodies  >29 publications with Gas-6 and Disease Models, Animal
 Thrombosis Antibodies  >29 publications with Gas-6 and Thrombosis
 Kidney Diseases Antibodies  >26 publications with Gas-6 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >14 publications with Gas-6 and Neoplasms, Experimental
 Prostatic Diseases Antibodies  >10 publications with Gas-6 and Prostatic Diseases
 Adenocarcinoma Antibodies  >10 publications with Gas-6 and Adenocarcinoma

Organs/Tissues associated with anti-Gas-6 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >44 publications with Gas-6 and Muscle
 Bone Antibodies  >42 publications with Gas-6 and Bone
 Kidney Antibodies  >32 publications with Gas-6 and Kidney
 Brain Antibodies  >27 publications with Gas-6 and Brain
 Bone Marrow Antibodies  >25 publications with Gas-6 and Bone Marrow
 Liver Antibodies  >22 publications with Gas-6 and Liver
 Lung Antibodies  >16 publications with Gas-6 and Lung
 Embryonic Tissue Antibodies  >15 publications with Gas-6 and Embryonic Tissue
 Eye Antibodies  >14 publications with Gas-6 and Eye
 Heart Antibodies  >11 publications with Gas-6 and Heart
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