Integrin Alpha 4 (ITGA4) Antibody – Mouse Monoclonal

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008]

Function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

Subunit structure: Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Interacts with AMICA1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling AMICA1 homodimerization. Ref.9 Ref.10

Subcellular location: Membrane; Single-pass type I membrane protein.

Domain: The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion. Ref.9

Post-translational modification: Phosphorylation on Ser-1027 inhibits PXN binding.

Sequence similarities: Belongs to the integrin alpha chain family.Contains 7 FG-GAP repeats.

Sequence caution: The sequence AAB59613.1 differs from that shown. Reason: Frameshift at position 13. The sequence CAA34852.1 differs from that shown. Reason: Frameshift at position 13.