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CXCL7 (PPBP) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8111094

Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2/PPBP/CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth… More details

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Product Overview

Online Datasheet in PDF
Product Name
CXCL7 (PPBP), Polyclonal Antibody
Full Product Name
Anti-CXCL7 Antibody, Rabbit Polyclonal
Product Gene Name
anti-PPBP antibody
Product Synonym Names
NAP-2/PPBP/CXCL7 Antibody, Rabbit PAb, Antigen Affinity Purified; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7); Anti-2400003M24Rik Antibody; Anti-AI854500 Antibody; Anti-b-TG1 Antibody; Anti-beta-TG Antibody; Anti-CTAP3 Antibody; Anti-CTAPIII Antibody; Anti-Cxcl7 Antibody; Anti-LA-PF4 Antibody; Anti-LDGF Antibody; Anti-MDGF Antibody; Anti-NAP-2 Antibody; Anti-NAP-2-L1 Antibody; Anti-Scyb7 Antibody; Anti-TGB Antibody; Anti-TGB1 Antibody; Anti-THBGB1 Antibody
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Liquid; 0.2um filtered solution in PBS
Purity/Purification
Protein A & Antigen Affinity
Specificity
Mouse NAP-2/PPBP/CXCL7
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Chromosome Location
Chromosome: 5; NC_000071.6 (90768518..90770060). Location: 5 E1; 5
3D Structure
ModBase 3D Structure for Q9EQI5
Immunogen
Recombinant Mouse NAP-2/PPBP/CXCL7 protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Mouse NAP-2/PPBP/CXCL7. NAP-2/PPBP/CXCL7 specific IgG was purified by Mouse NAP-2/PPBP/CXCL7 affinity chromatography.
Applications Tested/Suitable for anti-PPBP antibody
Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
Application Notes for anti-PPBP antibody
WB: 1:500-1:2000
ELISA: 1:5000-1:10,000
IP: 0.5-2uL/mg of lysate

Western Blot (WB) of anti-PPBP antibody

Anti-CXCL7(61) rabbit polyclonal antibody at 1:500 dilution
Lane A: 293T Whole Cell Lysate

Lysates/proteins at 30 ug per lane.
Secondary
Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.
Performed under reducing conditions.

Predicted band size:14 kDa
Observed band size:16 kDa
Rabbit Anti-PPBP Polyclonal Antibody – Cat# MBS8111094

Immunoprecipitation (IP) of anti-PPBP antibody

Mouse CXCL7 was immunoprecipitated using:
Lane A:0.5 mg 293T Whole Cell Lysate

2 uL anti-Mouse CXCL7 rabbit polyclonal antibody and 15 ul of 50 % Protein G agarose.

Primary antibody:
Anti-Mouse CXCL7 rabbit polyclonal antibody,at 1:200 dilution

Secondary antibody:
Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution

Developed using the odssey technique.
Performed under reducing conditions.

Predicted band size: 16 kDa
Observed band size: 16 kDa
Rabbit Anti-PPBP Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS8111094

Product References and Citations for anti-PPBP antibody

Walz A, et al. (1989) Effects of the neutrophil-activating peptide NAP-2, platelet basic protein, connective tissue-activating peptide III and platelet factor 4 on human neutrophils. J Exp Med. 170(5):1745-50.
Walz A, et al. (1990) Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases. J Exp Med. 171(2): 449-54.
Loetscher P, et al. (1994) Both interleukin-8 receptors independently mediate chemotaxis. Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GRO alpha and NAP-2. FEBS Lett. 341(2-3): 187-92.

Other Notes

Small volumes of anti-PPBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPBP purchase

MBS8111094 is an antibody targeting PPBP. Also known as Anti-CXCL7 Antibody, Rabbit Polyclonal. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PPBP. It may not necessarily be applicable to this product.

NCBI GI #
12963823
NCBI GeneID
57349
NCBI Accession #
NP_076274.1
UniProt Primary Accession #
Q9EQI5
GenBank Nucleotide #
NM_023785.2
NCBI Official Full Name
platelet basic protein
NCBI Official Synonym Full Names
pro-platelet basic protein
NCBI Official Symbol
Ppbp
NCBI Official Synonym Symbols
TGB; LDGF; MDGF; TGB1; CTAP3; Cxcl7; NAP-2; Scyb7; b-TG1; LA-PF4; THBGB1; CTAPIII; beta-TG; AI854500; NAP-2-L1; 2400003M24Rik
UniProt Protein Name
Chemokine (C-X-C motif) ligand 7, isoform CRA_b
Protein Family
Platelet basic protein
UniProt Gene Name
Ppbp
UniProt Synonym Gene Names
Cxcl7
UniProt Entry Name
Q9EQI5_MOUSE
NCBI Protein Information
platelet basic protein; chemokine (C-X-C motif) ligand 7

UniProt Comments for PPBP

Subcellular location: Secreted

By similarity SAAS SAAS001089.

Research Articles on PPBP

1. These results suggest that Cxcl4 and Cxcl7 play a role in the development of neurobehavioral alterations that are triggered by in utero TCDD exposure and later surface in adults.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PPBP antibody

 Reference Product  PubMed Publications
 Pf4 antibody  >15 publications with PPBP and Pf4
 Cxcr2 antibody  >10 publications with PPBP and Cxcr2
 Ccl5 antibody  >5 publications with PPBP and Ccl5
 Cxcr1 antibody  >5 publications with PPBP and Cxcr1
 Ccr2 antibody  >1 publications with PPBP and Ccr2

Pathways associated with anti-PPBP antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with anti-PPBP antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >35 publications with PPBP and Inflammation
 Cardiovascular Diseases Antibodies  >27 publications with PPBP and Cardiovascular Diseases
 Heart Diseases Antibodies  >12 publications with PPBP and Heart Diseases
 Neoplasms Antibodies  >10 publications with PPBP and Neoplasms
 Ischemia Antibodies  >9 publications with PPBP and Ischemia
 Lung Diseases Antibodies  >7 publications with PPBP and Lung Diseases
 Necrosis Antibodies  >6 publications with PPBP and Necrosis
 Immune System Diseases Antibodies  >6 publications with PPBP and Immune System Diseases
 Atherosclerosis Antibodies  >5 publications with PPBP and Atherosclerosis
 Pulmonary Edema Antibodies  >2 publications with PPBP and Pulmonary Edema

Organs/Tissues associated with anti-PPBP antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >8 publications with PPBP and Lung
 Embryonic Tissue Antibodies  >5 publications with PPBP and Embryonic Tissue
 Heart Antibodies  >4 publications with PPBP and Heart
 Liver Antibodies  >2 publications with PPBP and Liver
 Spleen Antibodies  >2 publications with PPBP and Spleen
 Lymph Node Antibodies  >1 publications with PPBP and Lymph Node
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