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OSCAR Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690316

OSCAR is a type I transmembrane protein that belongs to the leukocyte receptor complex (LRC) protein family. It is expressed specifically in preosteoclasts and mature osteoclasts. OSCAR may be an important regulator of osteoclast differentiation. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
OSCAR, Monoclonal Antibody
Full Product Name
Mouse Anti-Human OSCAR
Product Gene Name
Product Synonym Names
OSCAR; PIGR3
Clonality
Monoclonal
Isotype
IgG2
Clone Number
(6S6)
Host
Mouse
Species Reactivity
Human
Form/Format
Lyophilized
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
Molecular Weight
30,481 Da
Chromosome Location
Chromosome: 19; NC_000019.10 (54094668..54102686, complement). Location: 19q13.42
OMIM
606862
3D Structure
ModBase 3D Structure for Q8IYS5
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of OSCAR extracellular domain.
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-OSCAR antibody
Western Blot (WB)

Other Notes

Small volumes of anti-OSCAR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OSCAR purchase

MBS690316 is an antibody targeting OSCAR. Also known as Mouse Anti-Human OSCAR. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for OSCAR. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
osteoclast-associated immunoglobulin-like receptor isoform 6
NCBI Official Synonym Full Names
osteoclast associated, immunoglobulin-like receptor
NCBI Official Symbol
OSCAR
NCBI Official Synonym Symbols
PIGR3; PIgR-3
UniProt Protein Name
Osteoclast-associated immunoglobulin-like receptor
UniProt Synonym Protein Names
Polymeric immunoglobulin receptor 3
UniProt Gene Name
OSCAR
UniProt Synonym Gene Names
Osteoclast-associated receptor; hOSCAR; PIgR-3; PIgR3
UniProt Entry Name
OSCAR_HUMAN
NCBI Protein Information
osteoclast-associated immunoglobulin-like receptor; poly-Ig receptor 3; polymeric immunoglobulin receptor 3; osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2

NCBI Summary for OSCAR

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
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UniProt Comments for OSCAR

Function: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation

By similarity.

Subcellular location: Isoform 1: Secreted

Potential. Isoform 2: Cell membrane; Single-pass type I membrane protein

Potential.

Sequence similarities: Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family.Contains 2 Ig-like (immunoglobulin-like) domains.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OSCAR antibody

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