GDNF R alpha 3 Antibody – Mouse Monoclonal

Function: Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. Ref.7

Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor.

Tissue specificity: Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system. Ref.1

Post-translational modification: N-glycosylated. Ref.8

Sequence similarities: Belongs to the GDNFR family.