P-Selectin (SELP) Antibody – Rat Monoclonal

Mouse -P-Selectin (GMP140, LECAM3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. P- Selectin is translocated to the cell surface within minutes, from alpha granules of platelets or WeibelPalade bodies of endothelial cells, following stimulation with thrombin, histamine, PMA or peroxides. P-Selectin binds to a 106 kDa protein present on myeloid cells, neutrophils, monocytes and lymphocytes, termed PSGL 1 (PSelectin glycoprotein ligand1). PSelectin plays a role in the adhesion of leukocytes and neutrophils to the endothelium. Acting in cooperation with LSelectin, PSelectin mediates the initial interaction of circulating leukocytes with endothelial cells that produces a characteristic "˜rolling' of the leukocytes on the endothelium. This initial interaction is followed by a stronger interaction involving ESelectin, and later ICAM1 and VCAM1, that leads eventually to extravasation of the white blood cell through the blood vessel wall into the extracellular matrix tissue. Mouse P-Selectin cDNA encodes a 768 amino acid (aa) residue type I transmembrane protein with a 41 aa signal peptide, a 668 aa extracellular domain, a transmembrane domain and a short (35 aa) cytoplasmic domain. The extracellular domain has an NH2t-erminal C-type lectin domain and an EGF like domain followedby a series of of complement factor A repeat homology domains. The extracellular domains of human and mouse P-Selectin share approximately 73% sequence homology.

Small volumes of anti-Selp antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS690352 is an antibody targeting Selp. Also known as Rat Anti-Mouse P-Selectin. Reactive in Mouse. Host: Rat.