Mouse Anti-IL-1F8 Monoclonal Antibody – Cat# MBS690386

IL-1F8 Antibody – Mouse Monoclonal

Name: IL-1F8 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690386
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690386

The IL-1 family of cytokines is a set of structurally related molecules that are primary mediators of inflammation. This family now consists of 11 cytokines and 9 cell-surface receptors, the best characterized of which are IL-1alpha, IL-1beta, IL-1 receptor… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IL-1F8, Monoclonal Antibody

Full Product Name

Mouse Anti-Human IL-1F8

Product Gene Name

anti-IL-1F8 antibody

Product Synonym Names

IL36B; FIL1; FIL1H; IL1F8; IL1H2; IL-1F8; IL-1H2; IL1-ETA; FIL1-(ETA); FILI-(ETA)

Clonality

Monoclonal

Isotype

IgG1

Clone Number

(2Q27)

Host

Mouse

Species Reactivity

Human

Form/Format

Lyophilized

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

18,522 Da

Chromosome Location

Chromosome: 2; NC_000002.12 (113022091..113052867, complement). Location: 2q14

OMIM

605508

3D Structure

ModBase 3D Structure for Q9NZH7

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of IL-1F8.

Reconstitution

Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-IL-1F8 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-IL-1F8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-1F8 purchase

MBS690386 is an antibody targeting IL-1F8. Also known as Mouse Anti-Human IL-1F8. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-1F8. It may not necessarily be applicable to this product.

NCBI GI #

20070252

NCBI GeneID

27177

NCBI Accession #

NP_055253.2

UniProt Primary Accession #

Q9NZH7

UniProt Secondary Accession #

Q3MIH0; Q53SR6; Q7RTZ7; Q9UHA5

UniProt Related Accession #

Q9NZH7

GenBank Nucleotide #

NM_014438.4

NCBI Official Full Name

interleukin-36 beta isoform 1

NCBI Official Synonym Full Names

interleukin 36, beta

NCBI Official Symbol

IL36B

NCBI Official Synonym Symbols

FIL1; FIL1H; IL1F8; IL1H2; IL-1F8; IL-1H2; IL1-ETA; FIL1-(ETA); FILI-(ETA)

UniProt Protein Name

Interleukin-36 beta

UniProt Synonym Protein Names

FIL1 eta; Interleukin-1 eta; IL-1 eta; Interleukin-1 family member 8; IL-1F8; Interleukin-1 homolog 2

Protein Family

Interleukin

UniProt Gene Name

IL36B

UniProt Synonym Gene Names

IL1F8; IL1H2; IL-1 eta; IL-1F8; IL-1H2

UniProt Entry Name

IL36B_HUMAN

NCBI Protein Information

interleukin-36 beta; FIL1 eta; IL-1 eta; IL-1F8 (FIL1-eta); interleukin-1 eta; interleukin 1, eta; interleukin-1 homolog 2; Interleukin-1 Superfamily e; family of interleukin 1-eta; interleukin-1 family member 8; IL1F8 (Canonical product IL-1F8a); interleukin 1 family, member 8 (eta)

NCBI Summary for IL-1F8

The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

UniProt Comments for IL-1F8

Function: Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Ref.8 Ref.9 Ref.10

Subcellular location: Secreted

Potential.

Tissue specificity: Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue. Ref.9 Ref.10

Induction: By proinflammatory cytokines IL1A, IL1B and TNF in synovial fibroblasts. By IL1A and TNF in keratinocytes. Constitutive in articular chondrocytes. Ref.8

Sequence similarities: Belongs to the IL-1 family.

Research Articles on IL-1F8

1. Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-IL-1F8 antibody

Disease Name	Pubmed Publications
Skin Diseases Antibodies	>2 publications with IL-1F8 and Skin Diseases
Inflammation Antibodies	>2 publications with IL-1F8 and Inflammation
Death Antibodies	>1 publications with IL-1F8 and Death
Periodontitis Antibodies	>1 publications with IL-1F8 and Periodontitis