Angiopoietin-4 (ANGPT4) Antibody – Mouse Monoclonal

Human Angiopoietin4 (Ang4), alternatively named Ang3, is a secreted glycoprotein belonging to the angiopoietin family. It has the characteristic structural motifs of angiopoietins including the coiledcoiled domain near the aminoterminus and a fibrinogen like domain at the Cterminus. Human Ang 4 cDNA encodes a 503 amino acid (aa) precursor protein with a 23 aa signal peptide. It shares 45%, 47%, and 54% aa sequence identity with human Ang1, human Ang2, and mouse Ang3, respectively. Although the sequence homology is much higher between the human and mouse counterparts for Ang1 (97%) and Ang2 (85%), mouse Ang3 is believed to be an ortholog of human Ang4 based on chromosomal localization studies. Human Ang4 is highly expressed in lung and in cultured human umbilical vein endothelial cells (HUVECs). In contrast, mouse Ang3 is expressed multiple mouse tissues. Human Ang4 is an agonist that can bind and activate Tie2, a receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology domains expressed primarily on endothelial cells and early hematopoietic cells. Mouse Ang3 has been reported to be a Tie2 antagonist. It is likely that mouse Ang3, like Ang2, may exert agonist or antagonist activities depending on the cell context.

Small volumes of anti-ANGPT4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS690402 is an antibody targeting ANGPT4. Also known as Mouse Anti-Human Angiopoietin-4. Reactive in Human. Host: Mouse.