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Chordin (CHRD) Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690405

Chordin is a secreted glycoprotein that regulates dorsoventral patterning during gastrulation. Chordin functions as a bone morphogenetic protein (BMP) antagonist that blocks BMP ventralizing activity by binding to the BMPs and inhibiting their interaction… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
Chordin (Chrd), Monoclonal Antibody
Full Product Name
Rat Anti-Mouse Chordin
Product Gene Name
anti-Chrd antibody
Product Synonym Names
Chrd; Chd
Clonality
Monoclonal
Isotype
IgG2
Clone Number
(16B6)
Host
Rat
Species Reactivity
Mouse
Form/Format
Lyophilized
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
Chromosome Location
Chromosome: 16; NC_000082.6 (20731576..20742384). Location: 16 B1; 16 12.51 cM
3D Structure
ModBase 3D Structure for Q9ZoE2
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of Chordin.
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-Chrd antibody
Western Blot (WB)

Other Notes

Small volumes of anti-Chrd antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Chrd purchase

MBS690405 is an antibody targeting Chrd. Also known as Rat Anti-Mouse Chordin. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for Chrd. It may not necessarily be applicable to this product.

NCBI GeneID
12667
UniProt Primary Accession #
Q9ZoE2
UniProt Related Accession #
Q9Z0E2
NCBI Official Synonym Full Names
chordin
NCBI Official Symbol
Chrd
NCBI Official Synonym Symbols
Chd
Protein Family
Chordin
NCBI Protein Information
chordin

UniProt Comments for Chrd

CHRD: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. Belongs to the chordin family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; syndecan binding; protein binding

Biological Process: BMP signaling pathway in spinal cord dorsal-ventral patterning; central nervous system development; positive regulation of cell adhesion; multicellular organismal development; gastrulation with mouth forming second; pattern specification process; negative regulation of BMP signaling pathway; osteoblast differentiation; dorsal/ventral pattern formation; mesoderm formation; forebrain development; positive regulation of mesenchymal cell proliferation; negative regulation of osteoblast differentiation; negative regulation of cell migration; skeletal development
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Research Articles on Chrd

1. Chordin upregulated in primary satellite cell cultures and in regenerating muscles

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Chrd antibody

 Products by Pathway  Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
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