LOX-1 Antibody – Rat Monoclonal

Function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria

By similarity.

Subunit structure: Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70

By similarity.

Subcellular location: Cell membrane; Lipid-anchor

By similarity. Cell membrane; Single-pass type II membrane protein

By similarity. Membrane raft

By similarity. Secreted

By similarity. Note: A secreted form also exists. Localization to membrane rafts requires palmitoylation

By similarity.

Domain: The cytoplasmic region is required for subcellular sorting on the cell surface

By similarity.The C-type lectin domain mediates the recognition and binding of oxLDL

By similarity.The Neck region contains 3 internal repeats that are only found in rodents.

Post-translational modification: N-glycosylated

By similarity.

Sequence similarities: Contains 1 C-type lectin domain.