Mouse Anti-CCL-25 Monoclonal Antibody – Cat# MBS690434

CCL-25 Antibody – Mouse Monoclonal

Name: CCL-25 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690434
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690434

CCL25 (thymus-expressed chemokine) is a CC chemokine that is distantly related (approximately 20% amino acid sequence identity) to other CC chemokines. Human CCL25 cDNA encodes a 150 aa precursor protein with a 23 aa signal peptide that is cleaved to yield a… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CCL-25, Monoclonal Antibody

Full Product Name

Mouse Anti-Human CCL-25

Product Gene Name

anti-CCL-25 antibody

Product Synonym Names

CCL25; TECK; Ckb15; SCYA25

Clonality

Monoclonal

Isotype

IgG1

Clone Number

(9G99)

Host

Mouse

Species Reactivity

Human

Form/Format

Lyophilized

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

16,609 Da

Chromosome Location

Chromosome: 19; NC_000019.10 (8052762..8062663). Location: 19p13.2

OMIM

602565

3D Structure

ModBase 3D Structure for O15444

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of CCL-25 (also called TECK).

Reconstitution

Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-CCL-25 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-CCL-25 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL-25 purchase

MBS690434 is an antibody targeting CCL-25. Also known as Mouse Anti-Human CCL-25. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL-25. It may not necessarily be applicable to this product.

NCBI GI #

323098324

NCBI GeneID

6370

NCBI Accession #

NP_001188288.1

UniProt Primary Accession #

O15444

UniProt Secondary Accession #

Q96KJ7; A1L4J4; A6NI52; A8K9E7; B5MCA5

UniProt Related Accession #

O15444

GenBank Nucleotide #

NM_001201359.1

NCBI Official Full Name

C-C motif chemokine 25 isoform 2

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 25

NCBI Official Symbol

CCL25

NCBI Official Synonym Symbols

TECK; Ckb15; SCYA25

UniProt Protein Name

C-C motif chemokine 25

UniProt Synonym Protein Names

Chemokine TECK; Small-inducible cytokine A25; Thymus-expressed chemokine

UniProt Gene Name

CCL25

UniProt Synonym Gene Names

SCYA25; TECK

UniProt Entry Name

CCL25_HUMAN

NCBI Protein Information

C-C motif chemokine 25; TECKvar; Ck beta-15; chemokine TECK; thymus expressed chemokine; thymus-expressed chemokine; small-inducible cytokine A25; small inducible cytokine subfamily A (Cys-Cys), member 25

NCBI Summary for CCL-25

This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

UniProt Comments for CCL-25

Function: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Subcellular location: Secreted.

Tissue specificity: Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.

Research Articles on CCL-25

1. CCL25 and CCR9 regulate colorectal cancer progression and invasion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCL-25 antibody

Reference Product	PubMed Publications
CCR9 antibody	>130 publications with CCL-25 and CCR9
CCL19 antibody	>24 publications with CCL-25 and CCL19
CCL20 antibody	>17 publications with CCL-25 and CCL20
CCR7 antibody	>16 publications with CCL-25 and CCR7
CXCL13 antibody	>11 publications with CCL-25 and CXCL13
CCR5 antibody	>11 publications with CCL-25 and CCR5
CCR6 antibody	>10 publications with CCL-25 and CCR6
CXCL9 antibody	>5 publications with CCL-25 and CXCL9
CXCR5 antibody	>4 publications with CCL-25 and CXCR5
CCL27 antibody	>3 publications with CCL-25 and CCL27

Pathways associated with anti-CCL-25 antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram

Diseases associated with anti-CCL-25 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>51 publications with CCL-25 and Inflammation
Gastrointestinal Diseases Antibodies	>35 publications with CCL-25 and Gastrointestinal Diseases
Immune System Diseases Antibodies	>29 publications with CCL-25 and Immune System Diseases
Neoplasms Antibodies	>24 publications with CCL-25 and Neoplasms
Necrosis Antibodies	>23 publications with CCL-25 and Necrosis
Neoplasm Metastasis Antibodies	>11 publications with CCL-25 and Neoplasm Metastasis
Liver Diseases Antibodies	>10 publications with CCL-25 and Liver Diseases
Lymphoma Antibodies	>7 publications with CCL-25 and Lymphoma
Carcinoma Antibodies	>7 publications with CCL-25 and Carcinoma
Atrophy Antibodies	>5 publications with CCL-25 and Atrophy

Organs/Tissues associated with anti-CCL-25 antibody

Organ/Tissue Name	Pubmed Publications
Thymus Antibodies	>80 publications with CCL-25 and Thymus
Lung Antibodies	>7 publications with CCL-25 and Lung
Stomach Antibodies	>5 publications with CCL-25 and Stomach
Testis Antibodies	>2 publications with CCL-25 and Testis
Mixed Antibodies	>1 publications with CCL-25 and Mixed