Mouse Anti-CCL-17 Monoclonal Antibody – Cat# MBS690435

CCL-17 Antibody – Mouse Monoclonal

Name: CCL-17 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690435
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690435

CCL17 is a novel CC chemokine identified using a signal sequence trap method. CCL17 cDNA encodes a highly basic 94 amino acid (aa)residue precursor protein with a 23 aa residue signal peptide that is cleaved to generate the 71 aa residue mature secreted… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CCL-17, Monoclonal Antibody

Full Product Name

Mouse Anti-Human CCL-17

Product Gene Name

anti-CCL-17 antibody

Product Synonym Names

CCL17; TARC; ABCD-2; SCYA17; A-152E5.3

Clonality

Monoclonal

Isotype

IgG1

Clone Number

(6J30)

Host

Mouse

Species Reactivity

Human

Form/Format

Lyophilized

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

10,507 Da

Chromosome Location

Chromosome: 16; NC_000016.10 (57404767..57416062). Location: 16q13

OMIM

601520

3D Structure

ModBase 3D Structure for Q92583

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of CCL-17 (also called thymus and activation-regulated chemokine (TARC)).

Reconstitution

Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-CCL-17 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-CCL-17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL-17 purchase

MBS690435 is an antibody targeting CCL-17. Also known as Mouse Anti-Human CCL-17. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL-17. It may not necessarily be applicable to this product.

NCBI GI #

4506829

NCBI GeneID

6361

NCBI Accession #

NP_002978.1

UniProt Primary Accession #

Q92583

UniProt Secondary Accession #

Q2M287; A0N0Q9

UniProt Related Accession #

Q92583

GenBank Nucleotide #

NM_002987.2

NCBI Official Full Name

C-C motif chemokine 17

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 17

NCBI Official Symbol

CCL17

NCBI Official Synonym Symbols

TARC; ABCD-2; SCYA17; A-152E5.3

UniProt Protein Name

C-C motif chemokine 17

UniProt Synonym Protein Names

CC chemokine TARC; Small-inducible cytokine A17; Thymus and activation-regulated chemokine

UniProt Gene Name

CCL17

UniProt Synonym Gene Names

SCYA17; TARC

UniProt Entry Name

CCL17_HUMAN

NCBI Protein Information

C-C motif chemokine 17; CC chemokine TARC; T cell-directed CC chemokine; small-inducible cytokine A17; thymus and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 17

NCBI Summary for CCL-17

This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Jul 2008]

UniProt Comments for CCL-17

Function: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. Ref.7

Subcellular location: Secreted.

Tissue specificity: Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.

Induction: By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes.

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.

Caution: Was originally (Ref.6) thought to be a ligand for CCR8.

Research Articles on CCL-17

1. Ginseng inhibited TARC expression via blockade of NF-kappaB activation in HaCaT cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCL-17 antibody

Reference Product	PubMed Publications
CCR4 antibody	>236 publications with CCL-17 and CCR4
CXCR3 antibody	>57 publications with CCL-17 and CXCR3
CCR5 antibody	>35 publications with CCL-17 and CCR5
CCR8 antibody	>34 publications with CCL-17 and CCR8
CCR3 antibody	>31 publications with CCL-17 and CCR3
CCR7 antibody	>22 publications with CCL-17 and CCR7
STAT6 antibody	>20 publications with CCL-17 and STAT6
CCR6 antibody	>19 publications with CCL-17 and CCR6
CCR1 antibody	>16 publications with CCL-17 and CCR1
CCR2 antibody	>12 publications with CCL-17 and CCR2

Pathways associated with anti-CCL-17 antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
IL4-mediated Signaling Events Pathway antibodies	IL4-mediated Signaling Events Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram

Diseases associated with anti-CCL-17 antibody

Disease Name	Pubmed Publications
Hypersensitivity Antibodies	>268 publications with CCL-17 and Hypersensitivity
Inflammation Antibodies	>247 publications with CCL-17 and Inflammation
Skin Diseases Antibodies	>206 publications with CCL-17 and Skin Diseases
Respiratory Tract Diseases Antibodies	>173 publications with CCL-17 and Respiratory Tract Diseases
Dermatitis, Atopic Antibodies	>149 publications with CCL-17 and Dermatitis, Atopic
Lung Diseases Antibodies	>141 publications with CCL-17 and Lung Diseases
Asthma Antibodies	>116 publications with CCL-17 and Asthma
Respiratory Hypersensitivity Antibodies	>111 publications with CCL-17 and Respiratory Hypersensitivity
Necrosis Antibodies	>99 publications with CCL-17 and Necrosis
Immunoproliferative Disorders Antibodies	>64 publications with CCL-17 and Immunoproliferative Disorders

Organs/Tissues associated with anti-CCL-17 antibody

Organ/Tissue Name	Pubmed Publications
Mammary Gland Antibodies	>1 publications with CCL-17 and Mammary Gland