TIM-1 Antibody – Mouse Monoclonal

The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

Function: May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4

By similarity. In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair. Ref.1 Ref.6

Subcellular location: Membrane; Single-pass type I membrane protein

Probable.

Tissue specificity: Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses. Ref.1

Induction: Up-regulated in the kidney in renal diseases (at protein level). Ref.6

Polymorphism: Infection by hepatitis A virus (HAV) protects individuals from atopy if they carry insertion of the variants Met-Thr-Thr-Val-Pro-157 and Met-Thr-Thr-Thr-Val-Pro-157. Modernisation has led to a reduction in HAV seroprevalence and thus, may be, to an increase of expression of atopy, such as asthma, allergic rhinitis and atopic dermatitis. Allelic variation does not affect HAV-infection rates in Caucasians, Asians and African Americans.

Miscellaneous: The extracellular part of the protein can be cleaved and detected in urine and is in correlation with the expression in the kidney.

Sequence similarities: Belongs to the immunoglobulin superfamily. TIM family.Contains 1 Ig-like V-type (immunoglobulin-like) domain.