CRIM1 Antibody – Mouse Monoclonal

This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]

Function: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface. Ref.5 Ref.7

Subunit structure: Interacts with BMP4 and BMP7. Ref.5

Subcellular location: Processed cysteine-rich motor neuron 1 protein: Secreted Ref.5. Cell membrane; Single-pass type I membrane protein Ref.5.

Tissue specificity: Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level). Ref.1 Ref.7

Post-translational modification: N-glycosylated. Ref.5 Ref.7

Sequence similarities: Contains 4 antistasin-like domains.Contains 1 IGFBP N-terminal domain.Contains 6 VWFC domains.

Sequence caution: The sequence BAD92376.1 differs from that shown. Reason: Erroneous initiation.