Rat Anti-LPAM-1 Monoclonal Antibody – Cat# MBS690598

LPAM-1 Antibody – Rat Monoclonal

Name: LPAM-1 Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690598
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690598

The antibody is specific for a combinatorial determinate of integrin alpha4beta7complex. Integrin alpha4beta7 is composed of a 150 kD (alpha4 or CD49d) and a 130 kD (beta7) heterodimer, also known as CD49d/beta7 or LPAM-1. Belonging to the Ig superfamily, it… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

LPAM-1, Monoclonal Antibody

Full Product Name

Rat Anti-Mouse LPAM-1

Product Gene Name

anti-LPAM-1 antibody

Product Synonym Names

Anti mouse LPAM-1 (#2G18)

Clonality

Monoclonal

Isotype

IgG2

Clone Number

(2G18)

Host

Rat

Species Reactivity

Mouse

Form/Format

The IgG fraction of culture supernatant was purified by Protein A/G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS). Lyophilized samples are stable for 2 years from date of receipt when stored at

Purity/Purification

Protein A/G affinity chromatography

Specificity

This antibody was selected for its ability to detect mouse CD45 positive leukocytes in IHC.

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

87,411 Da

Chromosome Location

Chromosome: 15; NC_000081.6 (102215994..102231938, complement). Location: 15 F3; 15 57.39 cM

3D Structure

ModBase 3D Structure for P26011

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with cell lysates of mouse lymphocytes. IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.

Reconstitution

Reconstitute the antibody with 400 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-LPAM-1 antibody

Immunohistochemistry (IHC) - Paraffin, Flow Cytometry (FC/FACS), Immunoprecipitation (IP)

Application Notes for anti-LPAM-1 antibody

1. Flow Cytometry: Yes (1:50-200) 2. IP: Yes (1:100-400) 3. Immunocytochemistry (Paraffin): Yes (1:100-200)

Other Notes

Small volumes of anti-LPAM-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LPAM-1 purchase

MBS690598 is an antibody targeting LPAM-1. Also known as Rat Anti-Mouse LPAM-1. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for LPAM-1. It may not necessarily be applicable to this product.

NCBI GI #

160708008

NCBI GeneID

16421

NCBI Accession #

NP_038594.2

UniProt Primary Accession #

P26011

UniProt Secondary Accession #

Q3U2M1; Q64656

UniProt Related Accession #

P26011

GenBank Nucleotide #

NM_013566.2

NCBI Official Full Name

integrin beta-7

NCBI Official Synonym Full Names

integrin beta 7

NCBI Official Symbol

Itgb7

NCBI Official Synonym Symbols

Ly69

UniProt Protein Name

Integrin beta-7

UniProt Synonym Protein Names

Integrin beta-P; M290 IEL antigen

UniProt Gene Name

Itgb7

UniProt Entry Name

ITB7_MOUSE

NCBI Protein Information

integrin beta-7; integrin beta-P; M290 IEL antigen

UniProt Comments for LPAM-1

Function: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is involved in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM1. Integrin alpha-E/beta-7 is a receptor for E-cadherin.

Subunit structure: Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E.

Subcellular location: Membrane; Single-pass type I membrane protein.

Sequence similarities: Belongs to the integrin beta chain family.Contains 1 VWFA domain.

Research Articles on LPAM-1

1. beta7 integrin expression on cells of the innate immune system contributes to the critical role of beta7 integrin in the process of B cell tolerance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-LPAM-1 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram

Diseases associated with anti-LPAM-1 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>6 publications with LPAM-1 and Neoplasms
Cardiovascular Diseases Antibodies	>3 publications with LPAM-1 and Cardiovascular Diseases
Inflammation Antibodies	>2 publications with LPAM-1 and Inflammation
Necrosis Antibodies	>1 publications with LPAM-1 and Necrosis

Organs/Tissues associated with anti-LPAM-1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>6 publications with LPAM-1 and Blood
Intestine Antibodies	>2 publications with LPAM-1 and Intestine
Bone Marrow Antibodies	>2 publications with LPAM-1 and Bone Marrow
Embryonic Tissue Antibodies	>1 publications with LPAM-1 and Embryonic Tissue
Lung Antibodies	>1 publications with LPAM-1 and Lung
Skin Antibodies	>1 publications with LPAM-1 and Skin