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TMEFF1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690620

Transmembrane Protein with EGF-like and two Follistatin-like domains 1 (TMEFF1) also known as tomoregulin-1 is a type I transmembrane glycoprotein. TMEFF1 contains two follistatin modules and an EGF domain in its extracellular domain, a transmembrane domain… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TMEFF1, Monoclonal Antibody
Full Product Name
Mouse Anti-Human TMEFF1
Product Gene Name
Product Synonym Names
TMEFF1; TR-1; H7365; C9orf2; CT120.1
Clonality
Monoclonal
Isotype
IgG2
Clone Number
(7S12)
Host
Mouse
Species Reactivity
Human
Form/Format
Lyophilized
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
Molecular Weight
40,934 Da
Chromosome Location
Chromosome: 9; NC_000009.12 (100441906..100577636). Location: 9q
OMIM
603421
3D Structure
ModBase 3D Structure for Q8IYR6
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with extracellular domain of Human Transmembrane protein wth EGF-like and two Follistatin-like domains (TMEFF1), also called Tomoregulin-1.
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-TMEFF1 antibody
Western Blot (WB)

Other Notes

Small volumes of anti-TMEFF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TMEFF1 purchase

MBS690620 is an antibody targeting TMEFF1. Also known as Mouse Anti-Human TMEFF1. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TMEFF1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
GenBank Nucleotide #
NCBI Official Full Name
MSANTD3-TMEFF1 fusion protein
NCBI Official Synonym Full Names
MSANTD3-TMEFF1 readthrough
NCBI Official Symbol
MSANTD3-TMEFF1
NCBI Official Synonym Symbols
C9orf3-TMEFF1; C9orf30-TMEFF1
UniProt Protein Name
Tomoregulin-1
UniProt Synonym Protein Names
H7365; Transmembrane protein with EGF-like and one follistatin-like domain
Protein Family
UniProt Gene Name
TMEFF1
UniProt Synonym Gene Names
C9orf2; TR-1
UniProt Entry Name
TEFF1_HUMAN
NCBI Protein Information
MSANTD3-TMEFF1 fusion protein

NCBI Summary for TMEFF1

This locus represents naturally occurring read-through transcription from the neighboring MSANTD3 (Myb/SANT-like DNA-binding domain containing 3) and TMEFF1 (transmembrane protein with EGF-like and two follistatin-like domains 1) genes. The read-through transcript encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Aug 2013]
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UniProt Comments for TMEFF1

Function: May inhibit NODAL and BMP signaling during neural patterning

By similarity. May be a tumor suppressor in brain cancers. Ref.5

Subunit structure: May interact with ST14.

Subcellular location: Cell membrane; Single-pass type I membrane protein Ref.5.

Tissue specificity: Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle. Down-regulated in brain tumors as compared to control brain tissues. Ref.5

Sequence similarities: Belongs to the tomoregulin family.Contains 1 EGF-like domain.Contains 2 Kazal-like domains.

Sequence caution: The sequence AAA64622.1 differs from that shown. Reason: Frameshift at positions 293 and 297. The sequence CAA58791.1 differs from that shown. Reason: Frameshift at positions 293 and 297.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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