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Hepatoma-Derived Growth Factor (HRP-1) Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690630

HDGF is a member of the hepatoma-derived growth factor family. HDGF plays a role as a secreted mitogen from the human hepatoma cell line Huh-7. HDGF is a nuclear targeted vascular smooth muscle cell mitogen as well as a heparin-binding protein that is greatly… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Hepatoma-derived growth factor (HRP-1), Monoclonal Antibody
Full Product Name
Rat Anti-Mouse Hepatoma-derived growth factor (HRP-1)
Product Gene Name
anti-HRP-1 antibody
Product Synonym Names
Anti-mouse Hepatoma-derived growth factor, Releated Protein-1 [HRP-1] (#5B24)
Clonality
Monoclonal
Isotype
IgG2
Clone Number
(5B24)
Host
Rat
Species Reactivity
Mouse
Form/Format
The IgG fraction of culture supernatant was purified by Protein A/G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS). Lyophilized samples are stable for 2 years from date of receipt when stored at
Purity/Purification
Protein A/G affinity chromatography
Specificity
This antibody detects mouse HRP-1 in Western blotting.
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
Molecular Weight
26,269 Da
Chromosome Location
Chromosome: 3; NC_000069.6 (87906321..87916132). Location: 3 F1; 3 38.78 cM
3D Structure
ModBase 3D Structure for P51859
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant protein of HPRG. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-HRP-1 antibody
Western Blot (WB)
Application Notes for anti-HRP-1 antibody
1. Western blot: Yes (1:500-1000)

Other Notes

Small volumes of anti-HRP-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HRP-1 purchase

MBS690630 is an antibody targeting HRP-1. Also known as Rat Anti-Mouse Hepatoma-derived growth factor (HRP-1). Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for HRP-1. It may not necessarily be applicable to this product.

NCBI GI #
188497724
NCBI GeneID
15191
NCBI Accession #
NP_032257.3
UniProt Primary Accession #
P51859
UniProt Secondary Accession #
Q8BPG7; Q9CYA4; Q9JK87
UniProt Related Accession #
P51859
GenBank Nucleotide #
NM_008231.4
NCBI Official Full Name
hepatoma-derived growth factor
NCBI Official Synonym Full Names
hepatoma-derived growth factor
NCBI Official Symbol
Hdgf
NCBI Official Synonym Symbols
AI118077; D3Ertd299e
UniProt Protein Name
Hepatoma-derived growth factor
Protein Family
Heterogeneous nuclear ribonucleoprotein
UniProt Gene Name
Hdgf
UniProt Synonym Gene Names
Tdrm1; HDGF
UniProt Entry Name
HDGF_MOUSE
NCBI Protein Information
hepatoma-derived growth factor

UniProt Comments for HRP-1

Function: Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor

By similarity.

Subunit structure: Monomer, and domain-swapped homodimer

By similarity.

Subcellular location: Cytoplasm

By similarity. Nucleus

By similarity.

Tissue specificity: Expressed predominantly in testis and skeletal muscle, to intermediate extents in heart, brain, lung, liver, and kidney, and to a minimal extent in spleen.

Domain: The PWWP domain harbors the heparin-binding sites and is responsible for DNA-binding, while the C-terminal region is essentially unstructured

By similarity.

Post-translational modification: Sumoylated with SUMO1. Sumoylation prevents binding to chromatin

By similarity.

Sequence similarities: Belongs to the HDGF family.Contains 1 PWWP domain.
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Research Articles on HRP-1

1. Up-regulation of hepatoma-derived growth factor facilities tumor progression in malignant melanoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-HRP-1 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Chaperone Genes By XBP1(S) Pathway antibodies  Activation Of Chaperone Genes By XBP1(S) Pathway Diagram
 Activation Of Chaperones By IRE1alpha Pathway antibodies  Activation Of Chaperones By IRE1alpha Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Unfolded Protein Response Pathway antibodies  Unfolded Protein Response Pathway Diagram

Diseases associated with anti-HRP-1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >23 publications with HRP-1 and Adenocarcinoma
 Liver Diseases Antibodies  >16 publications with HRP-1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >16 publications with HRP-1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >16 publications with HRP-1 and Liver Neoplasms
 Lung Neoplasms Antibodies  >15 publications with HRP-1 and Lung Neoplasms
 Gastrointestinal Diseases Antibodies  >12 publications with HRP-1 and Gastrointestinal Diseases
 Necrosis Antibodies  >9 publications with HRP-1 and Necrosis
 Disease Models, Animal Antibodies  >8 publications with HRP-1 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >5 publications with HRP-1 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >4 publications with HRP-1 and Neoplasms, Experimental

Organs/Tissues associated with anti-HRP-1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >24 publications with HRP-1 and Liver
 Lung Antibodies  >23 publications with HRP-1 and Lung
 Blood Antibodies  >15 publications with HRP-1 and Blood
 Muscle Antibodies  >13 publications with HRP-1 and Muscle
 Brain Antibodies  >11 publications with HRP-1 and Brain
 Kidney Antibodies  >8 publications with HRP-1 and Kidney
 Embryonic Tissue Antibodies  >7 publications with HRP-1 and Embryonic Tissue
 Testis Antibodies  >6 publications with HRP-1 and Testis
 Bone Antibodies  >6 publications with HRP-1 and Bone
 Heart Antibodies  >5 publications with HRP-1 and Heart
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