Mouse Anti-CRTAM Monoclonal Antibody – Cat# MBS690634

CRTAM Antibody – Mouse Monoclonal

Name: CRTAM Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690634
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690634

Human CRTAM is a 393 amino acid (aa), 80 kDa type I transmembrane glycoprotein. CRTAM is a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CRTAM, Monoclonal Antibody

Full Product Name

Mouse Anti-Human CRTAM

Product Gene Name

anti-CRTAM antibody

Product Synonym Names

CRTAM; CD355

Clonality

Monoclonal

Isotype

IgG2

Clone Number

(21A9)

Host

Mouse

Species Reactivity

Human

Form/Format

Lyophilized

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

44,641 Da

Chromosome Location

Chromosome: 11; NC_000011.10 (122838547..122872639). Location: 11q24.1

OMIM

612597

3D Structure

ModBase 3D Structure for O95727

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant CRTAM extracellular domain.

Reconstitution

Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-CRTAM antibody

Western Blot (WB), Flow Cytometry (FC/FACS)

Other Notes

Small volumes of anti-CRTAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRTAM purchase

MBS690634 is an antibody targeting CRTAM. Also known as Mouse Anti-Human CRTAM. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CRTAM. It may not necessarily be applicable to this product.

NCBI GI #

51593098

NCBI GeneID

56253

NCBI Accession #

NP_062550.2

UniProt Primary Accession #

O95727

UniProt Secondary Accession #

Q59EI1; Q6IRX2

UniProt Related Accession #

O95727

GenBank Nucleotide #

NM_019604.2

NCBI Official Full Name

cytotoxic and regulatory T-cell molecule

NCBI Official Synonym Full Names

cytotoxic and regulatory T cell molecule

NCBI Official Symbol

CRTAM

NCBI Official Synonym Symbols

CD355

UniProt Protein Name

Cytotoxic and regulatory T-cell molecule

UniProt Synonym Protein Names

Class-I MHC-restricted T-cell-associated molecule

Protein Family

Cytotoxic and regulatory T-cell molecule

UniProt Gene Name

CRTAM

UniProt Entry Name

CRTAM_HUMAN

NCBI Protein Information

cytotoxic and regulatory T-cell molecule; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; class-I MHC-restricted T-cell-associated molecule

NCBI Summary for CRTAM

The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]

UniProt Comments for CRTAM

Function: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Ref.4 UniProtKB Q149L7

Subunit structure: Interacts with CADM1. Ref.4 Ref.5

Subcellular location: Membrane; Single-pass type I membrane protein

Potential.

Tissue specificity: In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues. Ref.1 Ref.4 Ref.6

Sequence similarities: Belongs to the nectin family. Ref.6Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence caution: The sequence BAD93067.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on CRTAM

1. The expression of CRTAM in activated Vgamma9Vdelta2 T cells is quickly downregulated following interaction with Necl-2 on tumor cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRTAM antibody

Reference Product	PubMed Publications
CD96 antibody	>2 publications with CRTAM and CD96
SCRIB antibody	>1 publications with CRTAM and SCRIB

Pathways associated with anti-CRTAM antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies	Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with anti-CRTAM antibody

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>2 publications with CRTAM and Disease Models, Animal
Lung Neoplasms Antibodies	>1 publications with CRTAM and Lung Neoplasms
Nervous System Diseases Antibodies	>1 publications with CRTAM and Nervous System Diseases
Neoplasms, Experimental Antibodies	>1 publications with CRTAM and Neoplasms, Experimental

Organs/Tissues associated with anti-CRTAM antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>25 publications with CRTAM and Blood
Thymus Antibodies	>4 publications with CRTAM and Thymus
Brain Antibodies	>4 publications with CRTAM and Brain
Spleen Antibodies	>3 publications with CRTAM and Spleen
Lung Antibodies	>3 publications with CRTAM and Lung
Muscle Antibodies	>1 publications with CRTAM and Muscle