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IL-7 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690640

Interleukin 7 (IL-7), previously known as pre-B-cell growth factor and lymphopoietin-1, is expressed by adherent stromal cells from various tissues. Mouse IL-7 has approximately 65% amino acid sequence identity with human IL-7 and both proteins exhibit… More details

$435 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-7, Monoclonal Antibody
Full Product Name
Mouse Anti-Human IL-7
Product Gene Name
anti-IL-7 antibody
Product Synonym Names
Monoclonal antibody anti-human IL-7
Clonality
Monoclonal
Isotype
IgG1
Host
Mouse
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Protein A chromatography
Molecular Weight
20,187 Da
Chromosome Location
Chromosome: 8; NC_000008.11 (78732772..78805523, complement). Location: 8q12-q13
OMIM
146660
3D Structure
ModBase 3D Structure for P13232
Antibody Generation
Monoclonal antibodies were produced in BALB/c x C57BL/6 F1 mice using recombinant human IL-7 as the immunizing antigen. IgG1 antibody was purified from ascites fluid on a Protein A affinity column.
Buffer
PBS
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Application Notes for anti-IL-7 antibody
ELISA: A 1:10,000 dilution of a 1mg/ml antibody solution will give satisfactory results in an ELISA using a rabbit anti-mouse second antibody conjugated to alkaline phosphatase (Jackson Laboratories).

Other Notes

Small volumes of anti-IL-7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-7 purchase

MBS690640 is an antibody targeting IL-7. Also known as Mouse Anti-Human IL-7. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-7. It may not necessarily be applicable to this product.

NCBI GI #
4504677
NCBI GeneID
3574
NCBI Accession #
NP_000871.1
UniProt Primary Accession #
P13232
UniProt Secondary Accession #
Q5FBY5; Q5FBY9; A0N0L3
UniProt Related Accession #
P13232
GenBank Nucleotide #
NM_000880.3
NCBI Official Full Name
interleukin-7 isoform 1
NCBI Official Synonym Full Names
interleukin 7
NCBI Official Symbol
IL7
NCBI Official Synonym Symbols
IL-7
UniProt Protein Name
Interleukin-7
UniProt Gene Name
IL7
UniProt Synonym Gene Names
IL-7
UniProt Entry Name
IL7_HUMAN
NCBI Protein Information
interleukin-7

NCBI Summary for IL-7

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]
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UniProt Comments for IL-7

Function: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

Subcellular location: Secreted.

Sequence similarities: Belongs to the IL-7/IL-9 family.

Research Articles on IL-7

1. our data point toward an unexpected new role for IL-7 as a potential autocrine mediator of lymphatic drainage

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL-7 antibody

 Reference Product  PubMed Publications
 IL7R antibody  >12 publications with IL-7 and IL7R
 IL3 antibody  >9 publications with IL-7 and IL3
 IL2RG antibody  >9 publications with IL-7 and IL2RG
 IL2RA antibody  >8 publications with IL-7 and IL2RA
 JAK3 antibody  >8 publications with IL-7 and JAK3
 IL9 antibody  >7 publications with IL-7 and IL9
 FOXP3 antibody  >6 publications with IL-7 and FOXP3
 CSF2 antibody  >4 publications with IL-7 and CSF2
 JAK1 antibody  >2 publications with IL-7 and JAK1

Pathways associated with anti-IL-7 antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-7 Signaling Pathway antibodies  Interleukin-7 Signaling Pathway Diagram
 Interleukin-7 Signaling Pathway antibodies  Interleukin-7 Signaling Pathway Diagram

Diseases associated with anti-IL-7 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >61 publications with IL-7 and Neoplasms
 Inflammation Antibodies  >20 publications with IL-7 and Inflammation
 Necrosis Antibodies  >19 publications with IL-7 and Necrosis
 Lymphopenia Antibodies  >17 publications with IL-7 and Lymphopenia
 Nervous System Diseases Antibodies  >16 publications with IL-7 and Nervous System Diseases
 Multiple Sclerosis Antibodies  >15 publications with IL-7 and Multiple Sclerosis
 Neoplasms, Experimental Antibodies  >14 publications with IL-7 and Neoplasms, Experimental
 Carcinoma Antibodies  >9 publications with IL-7 and Carcinoma
 Hypersensitivity Antibodies  >6 publications with IL-7 and Hypersensitivity
 Cell Transformation, Neoplastic Antibodies  >6 publications with IL-7 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-IL-7 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >188 publications with IL-7 and Blood
 Bone Antibodies  >47 publications with IL-7 and Bone
 Thymus Antibodies  >37 publications with IL-7 and Thymus
 Lymph Node Antibodies  >20 publications with IL-7 and Lymph Node
 Skin Antibodies  >13 publications with IL-7 and Skin
 Spleen Antibodies  >10 publications with IL-7 and Spleen
 Liver Antibodies  >9 publications with IL-7 and Liver
 Brain Antibodies  >7 publications with IL-7 and Brain
 Intestine Antibodies  >6 publications with IL-7 and Intestine
 Kidney Antibodies  >4 publications with IL-7 and Kidney
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