NKp30 Antibody – Mouse Monoclonal

The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

Function: Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation. Ref.1 Ref.10 Ref.13

Subunit structure: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6. Ref.1 Ref.2 Ref.11 Ref.13 Ref.14 Ref.15 Ref.16

Subcellular location: Cell membrane; Single-pass type I membrane protein Ref.1.

Tissue specificity: Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. Ref.1 Ref.2

Polymorphism: A genetic variation in NCR3 is associated with mild malaria susceptibility [

MIM:609148].

Sequence similarities: Belongs to the natural cytotoxicity receptor (NCR) family.Contains 1 Ig-like (immunoglobulin-like) domain.