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CD105 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690735

The MJ7/18 monoclonal antibody reacts with the mouse CD105 molecule, also known as Endoglin. This 90 kDa disulfide-linked homodimer is expressed by vascular endothelial cells. It is suggested that CD105 functions in adhesion and embryonic angiogenesis. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD105/Endoglin, Monoclonal Antibody
Full Product Name
Rat Anti-Mouse CD105/Endoglin
Product Gene Name
anti-CD105 antibody
Product Synonym Names
Anti-mouse CD105/Endoglin-FITC (#MJ7/18); Cell surface MJ7/18 antigen; CD105; Endoglin
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
MJ7/18 / IgG2a
Host
Rat
Species Reactivity
Mouse
Form/Format
Liquid
Purity/Purification
Protein G purified
Concentration
200 ug/ml (lot specific)
Specificity
The unconjugated antibody will detect native mouse CD105 in Western analysis.
Preparation and Storage
Store protected from light at 2-8 degree C. DO NOT FREEZE!
Molecular Weight
70,021 Da
Chromosome Location
Chromosome: 2; NC_000068.7 (32646532..32682669). Location: 2 B; 2 22.09 cM
3D Structure
ModBase 3D Structure for Q63961
Immunogen
murine stromal cell line
Conjugation
FITC
Preparation
Monoclonal antibodies were produced by immunizing rats with inflamed mouse skin.
Buffer/Stabilizer
PBS; 1% BSA
Preservative
0,02% sodium azide
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-CD105 antibody
Flow Cytometry (FC/FACS)

Testing Data of anti-CD105 antibody

Rat Anti-CD105 Monoclonal Antibody – Cat# MBS690735

Testing Data #2 of anti-CD105 antibody

Rat Anti-CD105 Monoclonal Antibody, Testing Data #2 – Cat# MBS690735

Product References and Citations for anti-CD105 antibody

1. Cheifetz et al., J Biol Chem 267:19027, 1992 2. Parker et al., J Bone Miner Res 18:289, 2003 3. Barbara et al., J Biol Chem 274:584, 1999 4. McAllister et al., Nature Genet 8:345, 1994 5. Chen et al., Proc Natl Acad Sci 99:15468, 2002

Other Notes

Small volumes of anti-CD105 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD105 purchase

MBS690735 is an antibody targeting CD105. Also known as Rat Anti-Mouse CD105/Endoglin. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD105. It may not necessarily be applicable to this product.

NCBI GI #
226437647
NCBI GeneID
13805
NCBI Accession #
NP_031958.2
UniProt Primary Accession #
Q63961
UniProt Secondary Accession #
Q61520; Q8K100
UniProt Related Accession #
Q63961
GenBank Nucleotide #
NM_007932.2
NCBI Official Full Name
endoglin isoform 1
NCBI Official Synonym Full Names
endoglin
NCBI Official Symbol
Eng
NCBI Official Synonym Symbols
Endo; CD105; AI528660; AI662476; S-endoglin
UniProt Protein Name
Endoglin
UniProt Synonym Protein Names
Cell surface MJ7/18 antigen
UniProt Gene Name
Eng
UniProt Synonym Gene Names
Edg
UniProt Entry Name
EGLN_MOUSE
NCBI Protein Information
endoglin; transmembrane glycoprotein; cell surface MJ7/18 antigen

UniProt Comments for CD105

Function: Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells. Ref.7

Subunit structure: Homodimer that forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Interacts with GDF2

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Endoglin is restricted to endothelial cells in all tissues except bone marrow and is also found in stromal cells within the connective tissue of intestine, stomach, heart, skeletal muscle, uterus, ovary, oviduct, testis and thymus.
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Research Articles on CD105

1. these results underscore the importance of endoglin in both canonical and non-canonical TGFbeta signaling pathways modulating both the activation and quiescence of the endothelium during angiogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD105 antibody

 Products by Pathway  Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram

Diseases associated with anti-CD105 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6100 publications with CD105 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >5290 publications with CD105 and Cardiovascular Diseases
 Neoplasms Antibodies  >3672 publications with CD105 and Neoplasms
 Heart Diseases Antibodies  >2780 publications with CD105 and Heart Diseases
 Disease Models, Animal Antibodies  >668 publications with CD105 and Disease Models, Animal
 Hypertension Antibodies  >557 publications with CD105 and Hypertension
 Inflammation Antibodies  >532 publications with CD105 and Inflammation
 Liver Diseases Antibodies  >431 publications with CD105 and Liver Diseases
 Atherosclerosis Antibodies  >404 publications with CD105 and Atherosclerosis
 Necrosis Antibodies  >366 publications with CD105 and Necrosis

Organs/Tissues associated with anti-CD105 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >7333 publications with CD105 and Heart
 Bone Antibodies  >7124 publications with CD105 and Bone
 Brain Antibodies  >7112 publications with CD105 and Brain
 Muscle Antibodies  >6415 publications with CD105 and Muscle
 Skin Antibodies  >2641 publications with CD105 and Skin
 Connective Tissue Antibodies  >2181 publications with CD105 and Connective Tissue
 Eye Antibodies  >1859 publications with CD105 and Eye
 Lung Antibodies  >1772 publications with CD105 and Lung
 Liver Antibodies  >1395 publications with CD105 and Liver
 Bone Marrow Antibodies  >1174 publications with CD105 and Bone Marrow
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