Mouse Anti-KIR Monoclonal Antibody – Cat# MBS690772

KIR Antibody – Mouse Monoclonal

Name: KIR Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690772
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690772

The KIR gene family currently consists of 15 gene loci (KIR2DL1, KIR2DL2/L3, KIR2DL4, KIR2DL5A, KIR2DL5B, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1/S1, KIR3DL2, KIR3DL3 and two pseudogenes, KIR2DP1 and KIR3DP1) encoded within a 100-200 Kb region of… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

KIR, Monoclonal Antibody

Full Product Name

Mouse Anti-Human KIR

Product Gene Name

anti-KIR antibody

Product Synonym Names

GEM; KIR

Clonality

Monoclonal

Isotype

IgG2

Clone Number

(11G25)

Host

Mouse

Species Reactivity

Human

Form/Format

Lyophilized

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

33,949 Da

Chromosome Location

Chromosome: 8; NC_000008.11 (94249253..94262319, complement). Location: 8q13-q21

OMIM

600164

3D Structure

ModBase 3D Structure for P55040

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of KIR.

Reconstitution

Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-KIR antibody

Western Blot (WB)

Other Notes

Small volumes of anti-KIR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KIR purchase

MBS690772 is an antibody targeting KIR. Also known as Mouse Anti-Human KIR. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for KIR. It may not necessarily be applicable to this product.

NCBI GI #

4885263

NCBI GeneID

2669

NCBI Accession #

NP_005252.1

UniProt Primary Accession #

P55040

UniProt Secondary Accession #

B2RA31

UniProt Related Accession #

P55040

GenBank Nucleotide #

NM_005261.3

NCBI Official Full Name

GTP-binding protein GEM

NCBI Official Synonym Full Names

GTP binding protein overexpressed in skeletal muscle

NCBI Official Symbol

GEM

NCBI Official Synonym Symbols

KIR

UniProt Protein Name

GTP-binding protein GEM

UniProt Synonym Protein Names

GTP-binding mitogen-induced T-cell protein; RAS-like protein KIR

Protein Family

Kirola

UniProt Gene Name

GEM

UniProt Synonym Gene Names

KIR

UniProt Entry Name

GEM_HUMAN

NCBI Protein Information

GTP-binding protein GEM; RAS-like protein KIR; kinase-inducible Ras-like protein; GTP-binding mitogen-induced T-cell protein; GTP-binding protein overexpressed in skeletal muscle

NCBI Summary for KIR

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

UniProt Comments for KIR

Function: Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.

Subunit structure: Interacts with calmodulin in a Ca2+-dependent manner. Binds ROCK1. Ref.6 Ref.7

Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue specificity: Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.

Induction: By mitogens.

Post-translational modification: Phosphorylated on tyrosine residues.

Sequence similarities: Belongs to the small GTPase superfamily. RGK family.

Research Articles on KIR

1. Data show a mechanism by which GTPase Gem contributes to the mitotic progression by maintaining correct spindle length through the kinesin Kif9.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KIR antibody

Reference Product	PubMed Publications
GMIP antibody	>5 publications with KIR and GMIP
KIF9 antibody	>2 publications with KIR and KIF9
KIR2DL1 antibody	>1 publications with KIR and KIR2DL1

Diseases associated with anti-KIR antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>881 publications with KIR and Neoplasms
Lung Neoplasms Antibodies	>158 publications with KIR and Lung Neoplasms
Lung Diseases Antibodies	>151 publications with KIR and Lung Diseases
Neutropenia Antibodies	>122 publications with KIR and Neutropenia
Disease Models, Animal Antibodies	>108 publications with KIR and Disease Models, Animal
Cardiovascular Diseases Antibodies	>106 publications with KIR and Cardiovascular Diseases
Liver Neoplasms Antibodies	>105 publications with KIR and Liver Neoplasms
Nervous System Diseases Antibodies	>98 publications with KIR and Nervous System Diseases
Neoplasms, Experimental Antibodies	>95 publications with KIR and Neoplasms, Experimental
Liver Diseases Antibodies	>74 publications with KIR and Liver Diseases

Organs/Tissues associated with anti-KIR antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>342 publications with KIR and Blood
Lung Antibodies	>195 publications with KIR and Lung
Liver Antibodies	>187 publications with KIR and Liver
Brain Antibodies	>87 publications with KIR and Brain
Bone Antibodies	>78 publications with KIR and Bone
Pancreas Antibodies	>73 publications with KIR and Pancreas
Vascular Antibodies	>64 publications with KIR and Vascular
Muscle Antibodies	>63 publications with KIR and Muscle
Heart Antibodies	>54 publications with KIR and Heart
Skin Antibodies	>52 publications with KIR and Skin