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NKG2D Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690789

NKG2D is a type II transmembrane protein with an extracellular C-type lectin domain. It occurs as a disulfide-linked homodimer that associates with either the DAP12 or DAP10 transmembrane adapter proteins. NKG2D is expressed on NK cells and some T cell… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
NKG2D, Monoclonal Antibody
Full Product Name
Rat Anti-Mouse NKG2D
Product Gene Name
Product Synonym Names
Klrk1; Nkg2d; NKG2-D; D6H12S2489E
Clonality
Monoclonal
Isotype
IgG2
Clone Number
(4J50)
Host
Rat
Species Reactivity
Mouse
Form/Format
Lyophilized
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
Molecular Weight
26,710 Da
Chromosome Location
Chromosome: 6; NC_000072.6 (129610323..129623864, complement). Location: 6 F3; 6 63.44 cM
3D Structure
ModBase 3D Structure for O54709
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of NKG2D.
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-NKG2D antibody
Western Blot (WB)

Other Notes

Small volumes of anti-NKG2D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NKG2D purchase

MBS690789 is an antibody targeting NKG2D. Also known as Rat Anti-Mouse NKG2D. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for NKG2D. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
NKG2-D type II integral membrane protein isoform b
NCBI Official Synonym Full Names
killer cell lectin-like receptor subfamily K, member 1
NCBI Official Symbol
Klrk1
NCBI Official Synonym Symbols
Nkg2d; NKG2-D; D6H12S2489E
UniProt Protein Name
NKG2-D type II integral membrane protein
UniProt Synonym Protein Names
Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor
Protein Family
UniProt Gene Name
Klrk1
UniProt Synonym Gene Names
Nkg2d
UniProt Entry Name
NKG2D_MOUSE
NCBI Protein Information
NKG2-D type II integral membrane protein; NK cell receptor D; natural killer cell group 2D; NKG2-D-activating NK receptor

UniProt Comments for NKG2D

Function: Receptor for RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1. Involved in the immune surveillance exerted by T and B lymphocytes. Ref.5

Subunit structure: Homodimer. Interacts with DAP10. The interaction with DAP10 is required for NKG2D cell surface expression.

Subcellular location: Membrane; Single-pass type II membrane protein

By similarity.

Tissue specificity: Natural killer cells. Expressed on DC cells. Ref.7

Miscellaneous: Structurally distinct families of ligands for mouse and human NKG2D receptors have been characterized. They might be orthologs.

Sequence similarities: Contains 1 C-type lectin domain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-NKG2D antibody

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