Rat Anti-CD105 Monoclonal Antibody – Cat# MBS690796

CD105 Antibody – Rat Monoclonal

Name: CD105 Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690796
Price: 920 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690796

Endoglin, also known as CD105, is a type I integral transmembrane glycoprotein and is an accessory receptor for TGF-beta superfamily ligands. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta.… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CD105, Monoclonal Antibody

Full Product Name

Rat Anti-Mouse CD105/Endoglin

Product Gene Name

anti-CD105 antibody

Product Synonym Names

Anti mouse CD105/Endoglin (#6J9)

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

(6J9)

Host

Rat

Species Reactivity

Mouse

Form/Format

The antibody was purified from tissue culture supernatant by affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).

Purity/Purification

Protein G affinity chromatography

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

70,021 Da

Chromosome Location

Chromosome: 2; NC_000068.7 (32646532..32682669). Location: 2 B; 2 22.09 cM

3D Structure

ModBase 3D Structure for Q63961

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with recombinant mouse CD105 protein). IgG2a fraction of the culture supernatant was purified by Protein G affinity chromatography.

Reconstitution

Reconstitute the antibody with 400 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-CD105 antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-CD105 antibody

1. Western Blotting: Yes (1:500-1000) 2. Immunohistochemistry (Paraffin): Yes (1:100-400)

Other Notes

Small volumes of anti-CD105 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD105 purchase

MBS690796 is an antibody targeting CD105. Also known as Rat Anti-Mouse CD105/Endoglin. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD105. It may not necessarily be applicable to this product.

NCBI GI #

226437647

NCBI GeneID

13805

NCBI Accession #

NP_031958.2

UniProt Primary Accession #

Q63961

UniProt Secondary Accession #

Q61520; Q8K100

UniProt Related Accession #

Q63961

GenBank Nucleotide #

NM_007932.2

NCBI Official Full Name

endoglin isoform 1

NCBI Official Synonym Full Names

endoglin

NCBI Official Symbol

Eng

NCBI Official Synonym Symbols

Endo; CD105; AI528660; AI662476; S-endoglin

UniProt Protein Name

Endoglin

UniProt Synonym Protein Names

Cell surface MJ7/18 antigen

Protein Family

Endoglin

UniProt Gene Name

Eng

UniProt Synonym Gene Names

Edg

UniProt Entry Name

EGLN_MOUSE

NCBI Protein Information

endoglin; transmembrane glycoprotein; cell surface MJ7/18 antigen

UniProt Comments for CD105

Function: Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells. Ref.7

Subunit structure: Homodimer that forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Interacts with GDF2

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Endoglin is restricted to endothelial cells in all tissues except bone marrow and is also found in stromal cells within the connective tissue of intestine, stomach, heart, skeletal muscle, uterus, ovary, oviduct, testis and thymus.

Research Articles on CD105

1. these results underscore the importance of endoglin in both canonical and non-canonical TGFbeta signaling pathways modulating both the activation and quiescence of the endothelium during angiogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD105 antibody

Products by Pathway	Pathway Diagram
TGF Beta Signaling Pathway antibodies	TGF Beta Signaling Pathway Diagram
TGF-beta Receptor Signaling Pathway antibodies	TGF-beta Receptor Signaling Pathway Diagram
XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies	XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram

Diseases associated with anti-CD105 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>6100 publications with CD105 and Nervous System Diseases
Cardiovascular Diseases Antibodies	>5290 publications with CD105 and Cardiovascular Diseases
Neoplasms Antibodies	>3672 publications with CD105 and Neoplasms
Heart Diseases Antibodies	>2780 publications with CD105 and Heart Diseases
Disease Models, Animal Antibodies	>668 publications with CD105 and Disease Models, Animal
Hypertension Antibodies	>557 publications with CD105 and Hypertension
Inflammation Antibodies	>532 publications with CD105 and Inflammation
Liver Diseases Antibodies	>431 publications with CD105 and Liver Diseases
Atherosclerosis Antibodies	>404 publications with CD105 and Atherosclerosis
Necrosis Antibodies	>366 publications with CD105 and Necrosis

Organs/Tissues associated with anti-CD105 antibody

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>7333 publications with CD105 and Heart
Bone Antibodies	>7124 publications with CD105 and Bone
Brain Antibodies	>7112 publications with CD105 and Brain
Muscle Antibodies	>6415 publications with CD105 and Muscle
Skin Antibodies	>2641 publications with CD105 and Skin
Connective Tissue Antibodies	>2181 publications with CD105 and Connective Tissue
Eye Antibodies	>1859 publications with CD105 and Eye
Lung Antibodies	>1772 publications with CD105 and Lung
Liver Antibodies	>1395 publications with CD105 and Liver
Bone Marrow Antibodies	>1174 publications with CD105 and Bone Marrow