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TNFRSF6B Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690800

Decoy receptor 3 (DcR3), also called TNFRSF6B, TR6 and M68, is a member of the TNF receptor superfamily. DcR3 lacks a transmembrane sequence and is a secreted protein. DcR3 shares sequence identity with OPG (31%), TNF RII (29%) and Fas (17%), and is expressed… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TNFRSF6B, Monoclonal Antibody
Full Product Name
Mouse Anti-Human TNFRSF6B
Product Gene Name
Product Synonym Names
TNFRSF6B; M68; TR6; DCR3; M68E; DJ583P15.1.1
Clonality
Monoclonal
Isotype
IgG2
Clone Number
(4V24)
Host
Mouse
Species Reactivity
Human
Form/Format
Lyophilized
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
Molecular Weight
32,680 Da
Chromosome Location
Chromosome: 20; NC_000020.11 (63696651..63698698). Location: 20q13.3
OMIM
603361
3D Structure
ModBase 3D Structure for O95407
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant TNFRSF6B (also called Decoy receptor 3).
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-TNFRSF6B antibody
Western Blot (WB), Neutr

Other Notes

Small volumes of anti-TNFRSF6B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF6B purchase

MBS690800 is an antibody targeting TNFRSF6B. Also known as Mouse Anti-Human TNFRSF6B. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF6B. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 6B
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 6b, decoy
NCBI Official Symbol
TNFRSF6B
NCBI Official Synonym Symbols
M68; TR6; DCR3; M68E; DJ583P15.1.1
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 6B
UniProt Synonym Protein Names
Decoy receptor 3; DcR3; Decoy receptor for Fas ligand; M68
UniProt Gene Name
TNFRSF6B
UniProt Synonym Gene Names
DCR3; TR6; DcR3
UniProt Entry Name
TNF6B_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 6B; decoy receptor 3; decoy receptor for Fas ligand

NCBI Summary for TNFRSF6B

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
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UniProt Comments for TNFRSF6B

Function: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Ref.7

Subcellular location: Secreted.

Tissue specificity: Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Sequence similarities: Contains 4 TNFR-Cys repeats.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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