TSLP R Antibody – Mouse Monoclonal

The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Function: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2

By similarity. Implicated in the development of the hematopoietic system. Ref.3

Subunit structure: Heterodimer of CRLF2 and IL7R.

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Probable. Isoform 2: Secreted

Probable.

Tissue specificity: Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells.

Induction: Up-regulated in activated peripheral monocytes and THP-1 cells.

Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is important for association with JAKs.

Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Sequence similarities: Belongs to the type I cytokine receptor family. Type 5 subfamily.Contains 1 fibronectin type-III domain.