Mouse Anti-MCP-3 Monoclonal Antibody – Cat# MBS690904

MCP-3 Antibody – Mouse Monoclonal

Name: MCP-3 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690904
Price: 435 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690904

MCP2 and CCL7 are two monocyte chemotactic proteins produced by human MG63 osteosarcoma cells. Both MCP2 and CCL7 are members of the CC family of chemokines and share 62% and 71% amino acid sequence identity, respectively, with MCP1. CCL7 also shares 58%… More details

$435 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MCP-3, Monoclonal Antibody

Full Product Name

Mouse Anti-Human MCP-3

Product Gene Name

anti-MCP-3 antibody

Product Synonym Names

Monoclonal antibody anti-human MCP-3

Clonality

Monoclonal

Isotype

IgG1

Host

Mouse

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

Protein A chromatography

Molecular Weight

11,200 Da

Chromosome Location

Chromosome: 17; NC_000017.11 (34270216..34272242). Location: 17q11.2-q12

OMIM

158106

3D Structure

ModBase 3D Structure for P80098

Antibody Generation

Monoclonal antibodies were produced in C3H/HeJ mice using recombinant human MCP-3 as the immunizing antigen. IgG1 antibody was purified from ascites fluid on a Protein A affinity column.

Buffer

PBS

Neutralization

To yield one-half maximal inhibition [ND50] of the biological activity of hMCP-3 (100 ng/ml), a concentration of 1.0-3.0 ug/ml of this antibody is required.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Application Notes for anti-MCP-3 antibody

Western Blot: To detect hMCP-3 by Western Blot analysis this antibody can be used at a concentration of 0.5-1.0 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hMCP-3 is 2.0-4.0 ng/lane, under reducing conditions and 0.25-0.50 ng/lane, under non-reducing conditions.

Other Notes

Small volumes of anti-MCP-3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCP-3 purchase

MBS690904 is an antibody targeting MCP-3. Also known as Mouse Anti-Human MCP-3. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MCP-3. It may not necessarily be applicable to this product.

NCBI GI #

13435402

NCBI GeneID

6354

NCBI Accession #

NP_006264.2

UniProt Primary Accession #

P80098

UniProt Secondary Accession #

Q569J6

UniProt Related Accession #

P80098

GenBank Nucleotide #

NM_006273.3

NCBI Official Full Name

C-C motif chemokine 7

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 7

NCBI Official Symbol

CCL7

NCBI Official Synonym Symbols

FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7

UniProt Protein Name

C-C motif chemokine 7

UniProt Synonym Protein Names

Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; MCP-3; NC28; Small-inducible cytokine A7

Protein Family

Mastin

UniProt Gene Name

CCL7

UniProt Synonym Gene Names

MCP3; SCYA6; SCYA7; MCP-3

UniProt Entry Name

CCL7_HUMAN

NCBI Protein Information

C-C motif chemokine 7; small-inducible cytokine A7; monocyte chemotactic protein 3; monocyte chemoattractant protein 3; small inducible cytokine A7 (monocyte chemotactic protein 3)

NCBI Summary for MCP-3

This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]

UniProt Comments for MCP-3

Function: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

Subunit structure: Monomer. Ref.8

Subcellular location: Secreted.

Post-translational modification: O-glycosylated.

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.

Sequence caution: The sequence CAA50405.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA50406.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA51055.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on MCP-3

1. Systemic IFN-gamma triggered the secretion of C-C motif ligand chemokines CCL2 and CCL7 leading to the egress of early, myeloid-committed progenitors from the bone marrow mediated by their common receptor CCR2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MCP-3 antibody

Reference Product	PubMed Publications
CCL2 antibody	>233 publications with MCP-3 and CCL2
CCL5 antibody	>120 publications with MCP-3 and CCL5
CCR2 antibody	>88 publications with MCP-3 and CCR2
CCL11 antibody	>69 publications with MCP-3 and CCL11
CCR3 antibody	>43 publications with MCP-3 and CCR3
CCR1 antibody	>42 publications with MCP-3 and CCR1
CCR5 antibody	>36 publications with MCP-3 and CCR5
CCL17 antibody	>22 publications with MCP-3 and CCL17
CXCR3 antibody	>9 publications with MCP-3 and CXCR3
CCR10 antibody	>3 publications with MCP-3 and CCR10

Pathways associated with anti-MCP-3 antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with anti-MCP-3 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>169 publications with MCP-3 and Inflammation
Respiratory Tract Diseases Antibodies	>61 publications with MCP-3 and Respiratory Tract Diseases
Lung Diseases Antibodies	>53 publications with MCP-3 and Lung Diseases
Hypersensitivity Antibodies	>52 publications with MCP-3 and Hypersensitivity
Necrosis Antibodies	>48 publications with MCP-3 and Necrosis
Disease Models, Animal Antibodies	>45 publications with MCP-3 and Disease Models, Animal
Neoplasms Antibodies	>42 publications with MCP-3 and Neoplasms
Fibrosis Antibodies	>23 publications with MCP-3 and Fibrosis
Brain Diseases Antibodies	>22 publications with MCP-3 and Brain Diseases
Cardiovascular Diseases Antibodies	>20 publications with MCP-3 and Cardiovascular Diseases

Organs/Tissues associated with anti-MCP-3 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>259 publications with MCP-3 and Blood
Lung Antibodies	>68 publications with MCP-3 and Lung
Skin Antibodies	>30 publications with MCP-3 and Skin
Intestine Antibodies	>14 publications with MCP-3 and Intestine
Uterus Antibodies	>9 publications with MCP-3 and Uterus
Placenta Antibodies	>4 publications with MCP-3 and Placenta