Rat Anti-MIS Monoclonal Antibody – Cat# MBS690923

MIS Antibody – Rat Monoclonal

Name: MIS Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690923
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690923

MIS, also known as anti-MuÌˆllerianhormone (AMH), belongs to the TGFbeta superfamily. It is produced by the fetal testis and plays a central role in male sex differentiation. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MIS, Monoclonal Antibody

Full Product Name

Rat Anti-Mouse MIS

Product Gene Name

anti-MIS antibody

Product Synonym Names

Amh; MIS

Clonality

Monoclonal

Isotype

IgG2

Clone Number

(8D29)

Host

Rat

Species Reactivity

Mouse

Form/Format

Lyophilized

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

59,778 Da

Chromosome Location

Chromosome: 10; NC_000076.6 (80805018..80807679). Location: 10 C1; 10 39.72 cM

3D Structure

ModBase 3D Structure for P27106

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of MIS (also called anti-Mullerian hormone (AMH)).

Reconstitution

Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-MIS antibody

Western Blot (WB)

Other Notes

Small volumes of anti-MIS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MIS purchase

MBS690923 is an antibody targeting MIS. Also known as Rat Anti-Mouse MIS. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for MIS. It may not necessarily be applicable to this product.

NCBI GI #

127110

NCBI GeneID

11705

NCBI Accession #

P27106.1

UniProt Primary Accession #

P27106

UniProt Related Accession #

P27106

NCBI Official Full Name

Muellerian-inhibiting factor

NCBI Official Synonym Full Names

anti-Mullerian hormone

NCBI Official Symbol

Amh

NCBI Official Synonym Symbols

MIS

UniProt Protein Name

Muellerian-inhibiting factor

UniProt Synonym Protein Names

Anti-Muellerian hormone; AMH; Muellerian-inhibiting substance

Protein Family

Mis18-binding protein

UniProt Gene Name

Amh

UniProt Synonym Gene Names

AMH; MIS

UniProt Entry Name

MIS_MOUSE

NCBI Protein Information

muellerian-inhibiting factor; anti-Muellerian hormone; Mullerian inhibiting substance; muellerian-inhibiting substance

NCBI Summary for MIS

This gene is a member of the transforming growth factor-beta superfamily of growth and differentiation factors. The encoded protein is produced in fetal Sertoli cells during male gonadal differentiation. The protein binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in developing male embryos. In humans, some mutations in this gene are associated with persistent Mullerian duct syndrome (PMDS). [provided by RefSeq, Apr 2013]

UniProt Comments for MIS

Function: This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.

Subunit structure: Homodimer; disulfide-linked.

Subcellular location: Secreted

By similarity.

Tissue specificity: Sertoli cells of fetal testes, and testes just after birth, but absent in adult testes. In female, AMH is expressed after birth in the granulosa cells of the follicle. AMH expression is dependent on the degree of follicular maturation and not on the age of the ovary.

Miscellaneous: Although it does not compete with EGF for receptor binding sites, MIS can inhibit the autophosphorylation of the EGF receptor in vitro.

Sequence similarities: Belongs to the TGF-beta family.

Research Articles on MIS

1. Data show that Purkinje cells express receptors for Mullerian inhibiting substance (MIS), and that MIS(-/-) male mice have female-like numbers of Purkinje cells and a female-like size to other parts of their cerebellum.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MIS antibody

Reference Product	PubMed Publications
Sox9 antibody	>72 publications with MIS and Sox9
Amhr2 antibody	>30 publications with MIS and Amhr2
Gata4 antibody	>21 publications with MIS and Gata4
Bmpr2 antibody	>13 publications with MIS and Bmpr2
Kitl antibody	>4 publications with MIS and Kitl
Zfpm2 antibody	>3 publications with MIS and Zfpm2
Acvr1 antibody	>1 publications with MIS and Acvr1

Pathways associated with anti-MIS antibody

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TGF-beta Signaling Pathway antibodies	TGF-beta Signaling Pathway Diagram
TGF-beta Signaling Pathway antibodies	TGF-beta Signaling Pathway Diagram