Mouse Anti-CD23 Monoclonal Antibody – Cat# MBS690924

CD23 Antibody – Mouse Monoclonal

Name: CD23 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690924
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690924

CD23, also known as Fc epsilon RII, is a type 2 transmembrane C-type lectin that binds IgE, CD21, CD11b and CD11c. It is expressed on a variety of hematopoietic cells and functions in allergic immune responses. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CD23, Monoclonal Antibody

Full Product Name

Mouse Anti-Human CD23

Product Gene Name

anti-CD23 antibody

Product Synonym Names

FCER2; CD23; FCE2; CD23A; IGEBF; CLEC4J

Clonality

Monoclonal

Isotype

IgG1

Clone Number

(2C23)

Host

Mouse

Species Reactivity

Human

Form/Format

Lyophilized

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

36,469 Da

Chromosome Location

Chromosome: 19; NC_000019.10 (7688757..7702146, complement). Location: 19p13.3

OMIM

151445

3D Structure

ModBase 3D Structure for P06734

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of CD23 extracellular domain (also called Fc e RII).

Reconstitution

Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-CD23 antibody

Western Blot (WB), Flow Cytometry (FC/FACS), Neutr

Other Notes

Small volumes of anti-CD23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD23 purchase

MBS690924 is an antibody targeting CD23. Also known as Mouse Anti-Human CD23. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD23. It may not necessarily be applicable to this product.

NCBI GI #

334085205

NCBI GeneID

2208

NCBI Accession #

NP_001193948.2

UniProt Primary Accession #

P06734

UniProt Related Accession #

P06734

GenBank Nucleotide #

NM_001207019.2

NCBI Official Full Name

low affinity immunoglobulin epsilon Fc receptor isoform b

NCBI Official Synonym Full Names

Fc fragment of IgE, low affinity II, receptor for (CD23)

NCBI Official Symbol

FCER2

NCBI Official Synonym Symbols

CD23; FCE2; CD23A; IGEBF; CLEC4J; BLAST-2

UniProt Protein Name

Low affinity immunoglobulin epsilon Fc receptor

UniProt Synonym Protein Names

BLAST-2; C-type lectin domain family 4 member J; Fc-epsilon-RII; Immunoglobulin E-binding factor; Lymphocyte IgE receptor

Protein Family

Low affinity immunoglobulin epsilon Fc receptor

UniProt Gene Name

FCER2

UniProt Synonym Gene Names

CD23A; CLEC4J; FCE2; IGEBF

UniProt Entry Name

FCER2_HUMAN

NCBI Protein Information

low affinity immunoglobulin epsilon Fc receptor; CD23 antigen; fc-epsilon-RII; lymphocyte IgE receptor; immunoglobulin E-binding factor; C-type lectin domain family 4, member J

NCBI Summary for CD23

The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

UniProt Comments for CD23

Function: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Subunit structure: Homotrimer. Ref.12

Subcellular location: Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note: Also exists as a soluble excreted form, sCD23. Ref.8 Ref.9

Post-translational modification: N- and O-glycosylated.The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.

Miscellaneous: There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.

Sequence similarities: Contains 1 C-type lectin domain.

Sequence caution: The sequence AAA52433.1 differs from that shown. Reason: Erroneous gene model prediction.

Research Articles on CD23

1. The interplay of free IgE with IgE-allergen immune complexes of different sizes and composition with CD23 binding represents a mechanism for the modulation of CD23-mediated immune responses.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD23 antibody

Products by Pathway	Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
IL-3 Signaling Pathway antibodies	IL-3 Signaling Pathway Diagram
IL4-mediated Signaling Events Pathway antibodies	IL4-mediated Signaling Events Pathway Diagram
NOTCH2 Intracellular Domain Regulates Transcription Pathway antibodies	NOTCH2 Intracellular Domain Regulates Transcription Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By NOTCH Pathway antibodies	Signaling By NOTCH Pathway Diagram
Signaling By NOTCH2 Pathway antibodies	Signaling By NOTCH2 Pathway Diagram

Diseases associated with anti-CD23 antibody

Disease Name	Pubmed Publications
Asthma Antibodies	>14 publications with CD23 and Asthma
Lung Diseases Antibodies	>11 publications with CD23 and Lung Diseases
Hypersensitivity Antibodies	>10 publications with CD23 and Hypersensitivity
Respiratory Hypersensitivity Antibodies	>10 publications with CD23 and Respiratory Hypersensitivity
Hypersensitivity, Immediate Antibodies	>10 publications with CD23 and Hypersensitivity, Immediate
Neoplasms Antibodies	>5 publications with CD23 and Neoplasms
Inflammation Antibodies	>2 publications with CD23 and Inflammation
Hyperplasia Antibodies	>1 publications with CD23 and Hyperplasia
Intestinal Diseases Antibodies	>1 publications with CD23 and Intestinal Diseases
Bronchial Hyperreactivity Antibodies	>1 publications with CD23 and Bronchial Hyperreactivity

Organs/Tissues associated with anti-CD23 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>6 publications with CD23 and Blood
Lymph Node Antibodies	>1 publications with CD23 and Lymph Node
Spleen Antibodies	>1 publications with CD23 and Spleen