Thymopoietin (TMPO) Antibody – Mouse Monoclonal

The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010]

Function: May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

Subunit structure: Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at specific cell-cycle stages. Ref.7 Ref.8 Ref.9

Subcellular location: Nucleus. Chromosome. Note: Expressed diffusely throughout the nucleus.

Tissue specificity: Expressed in many tissues. Most abundant in adult thymus and fetal liver.

Domain: The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.The C-terminal domain forms a four-stranded coiled coil

By similarity.

Post-translational modification: Phosphorylated in a mitose-specific manner. Ref.7

Involvement in disease: Cardiomyopathy, dilated 1T (CMD1T) [MIM:613740]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.26

Pharmaceutical use: TP5 is available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) and Mepentil (Recordati). Used in primary and secondary immune deficiencies, autoimmunity, infections and cancer.

Sequence similarities: Belongs to the LEM family.Contains 1 LEM domain.Contains 1 LEM-like domain.