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GDNF R alpha 4 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691013

GDNF family receptor alpha-1 is a protein that in humans is encoded by the GFRA1 gene. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GDNF R alpha 4, Monoclonal Antibody
Full Product Name
Mouse Anti-Human GDNF R alpha 4
Product Synonym Names
glial cell line derived neurotrophic factor Receptor alpha 4
Clonality
Monoclonal
Isotype
IgG1
Clone Number
(3P34)
Host
Mouse
Species Reactivity
Human
Form/Format
Lyophilized
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
Molecular Weight
31,670 Da
Chromosome Location
Chromosome: 20; NC_000020.11 (3659292..3663399, complement). Location: 20p13-p12
3D Structure
ModBase 3D Structure for Q9GZZ7
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of GDNF-Ra4.
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-GDNF R alpha 4 antibody
Western Blot (WB)

Other Notes

Small volumes of anti-GDNF R alpha 4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDNF R alpha 4 purchase

MBS691013 is an antibody targeting GDNF R alpha 4. Also known as Mouse Anti-Human GDNF R alpha 4. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for GDNF R alpha 4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
GDNF family receptor alpha-4 isoform a
NCBI Official Synonym Full Names
GDNF family receptor alpha 4
NCBI Official Symbol
GFRA4
UniProt Protein Name
GDNF family receptor alpha-4
UniProt Synonym Protein Names
Persephin receptor
UniProt Gene Name
GFRA4
UniProt Synonym Gene Names
GDNF receptor alpha-4; GDNFR-alpha-4; GFR-alpha-4
UniProt Entry Name
GFRA4_HUMAN
NCBI Protein Information
GDNF family receptor alpha-4; GFR-alpha-4; GDNFR-alpha-4; persephin receptor; GFR receptor alpha 4; GDNF receptor alpha-4

NCBI Summary for GDNF R alpha 4

The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for GDNF R alpha 4

Function: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.

Subcellular location: Isoform GFRalpha4a: Cell membrane; Lipid-anchor › GPI-anchor Ref.1. Isoform GFRalpha4b: Cell membrane; Lipid-anchor › GPI-anchor Ref.1. Isoform GFRalpha4c: Secreted.

Tissue specificity: Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.

Sequence similarities: Belongs to the GDNFR family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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