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KC (CXCL1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691056

The predicted amino acid sequence of the mouse KC gene product indicates KC is a member of the CXC subfamily of chemokines. The protein sequence of mouse KC shows approximately 63% identity to that of mouse MIP-2. In addition, the protein sequence of KC is… More details

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Product Overview

Product Name
KC (CXCL1), Polyclonal Antibody
Full Product Name
Rabbit Anti-Mouse KC (CXCL1)
Product Gene Name
anti-KC (CXCL1) antibody
Product Synonym Names
Antigen-Affinity Purified Polyclonal Antibodies Anti-murine KC
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Lyophilized
Purity/Purification
Protein A chromatography
Molecular Weight
10,254 Da
Chromosome Location
Chromosome: 5; NC_000071.6 (90891245..90893121). Location: 5 E-F; 5 44.78 cM
3D Structure
ModBase 3D Structure for P12850
Antibody Generation
Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant murine KC. Anti-murine KC specific antibody was purified by affinity chromatography employing immobilized murine KC matrix.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-KC (CXCL1) antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-KC (CXCL1) antibody
Western Blot: To detect murine KC by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant murine KC is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-KC (CXCL1) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KC (CXCL1) purchase

MBS691056 is an antibody targeting KC (CXCL1). Also known as Rabbit Anti-Mouse KC (CXCL1). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KC (CXCL1). It may not necessarily be applicable to this product.

NCBI GI #
6680109
NCBI GeneID
14825
NCBI Accession #
NP_032202.1
UniProt Primary Accession #
P12850
UniProt Related Accession #
P12850
GenBank Nucleotide #
NM_008176.3
NCBI Official Full Name
growth-regulated alpha protein
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 1
NCBI Official Symbol
Cxcl1
NCBI Official Synonym Symbols
KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1
UniProt Protein Name
Growth-regulated alpha protein
UniProt Synonym Protein Names
C-X-C motif chemokine 1; Platelet-derived growth factor-inducible protein KC; Secretory protein N51Cleaved into the following chain:KC(5-72); Alternative name(s):; Hematopoietic synergistic factor; HSF; KC-T
UniProt Gene Name
Cxcl1
UniProt Synonym Gene Names
Gro; Gro1; Mgsa; Scyb1; HSF
UniProt Entry Name
GROA_MOUSE
NCBI Protein Information
growth-regulated alpha protein; KC/GR)-alpha; KC/GRO-alpha; GRO1 oncogene; alpha-chemokine; secretory protein N51; C-X-C motif chemokine 1; platelet-derived growth factor-inducible protein KC

NCBI Summary for KC (CXCL1)

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]
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UniProt Comments for KC (CXCL1)

Function: Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation

By similarity. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity. Ref.5

Subcellular location: Secreted.

Induction: By platelet-derived growth factor. In lung, by lipopolysaccharide or inflammation

By similarity.

Post-translational modification: The N-terminal processed form KC(5-72) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.

Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.
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Research Articles on KC (CXCL1)

1. excessive CXCL1 expression in gp130-deficient endothelial cells augments neutrophil adhesion but hinders migration, most likely by disrupting chemotactic gradients

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-KC (CXCL1) antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram

Diseases associated with anti-KC (CXCL1) antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1010 publications with KC (CXCL1) and Inflammation
 Necrosis Antibodies  >501 publications with KC (CXCL1) and Necrosis
 Disease Models, Animal Antibodies  >371 publications with KC (CXCL1) and Disease Models, Animal
 Lung Diseases Antibodies  >303 publications with KC (CXCL1) and Lung Diseases
 Neoplasms Antibodies  >294 publications with KC (CXCL1) and Neoplasms
 Cardiovascular Diseases Antibodies  >167 publications with KC (CXCL1) and Cardiovascular Diseases
 Lung Injury Antibodies  >163 publications with KC (CXCL1) and Lung Injury
 Gastrointestinal Diseases Antibodies  >153 publications with KC (CXCL1) and Gastrointestinal Diseases
 Pneumonia Antibodies  >106 publications with KC (CXCL1) and Pneumonia
 Wounds and Injuries Antibodies  >91 publications with KC (CXCL1) and Wounds and Injuries

Organs/Tissues associated with anti-KC (CXCL1) antibody

 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >55 publications with KC (CXCL1) and Connective Tissue
 Embryonic Tissue Antibodies  >38 publications with KC (CXCL1) and Embryonic Tissue
 Spinal Cord Antibodies  >27 publications with KC (CXCL1) and Spinal Cord
 Ovary Antibodies  >16 publications with KC (CXCL1) and Ovary
 Adipose Tissue Antibodies  >16 publications with KC (CXCL1) and Adipose Tissue
 Mammary Gland Antibodies  >7 publications with KC (CXCL1) and Mammary Gland
 Extraembryonic Tissue Antibodies  >1 publications with KC (CXCL1) and Extraembryonic Tissue
 Testis Antibodies  >1 publications with KC (CXCL1) and Testis
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