Rabbit Anti-TIE-1 Polyclonal Antibody – Cat# MBS691060

TIE-1 Antibody – Rabbit Polyclonal

Name: TIE-1 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS691060
Price: 425 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691060

TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TIE-1, Polyclonal Antibody

Full Product Name

Rabbit Anti-Mouse TIE-1

Product Gene Name

anti-TIE-1 antibody

Product Synonym Names

Anti-mouse TIE-1; Tyrosine protein kinase 1

Clonality

Polyclonal

Clone Number

Rabbit IgG

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Lyophilized

Purity/Purification

Protein A purified

Preparation and Storage

The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 degree C. Frozen aliquots are stable for at least 6 months when stored at -20 degree C.

Molecular Weight

124,583 Da

Chromosome Location

Chromosome: 4; NC_000070.6 (118471191..118489849, complement). Location: 4 D2.1; 4 54.67 cM

3D Structure

ModBase 3D Structure for Q06806

Immunogen

Recombinant mouse sTIE-1 (RT Cat# S01-M42)

Preparation

Produced from sera of rabbits pre-immunized with highly pure (>95%) recombinant mouse soluble TIE-1 (Ser22-Ala748) produced in insect cells.

Buffer

PBS

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-TIE-1 antibody

Western Blot (WB)

Application Notes for anti-TIE-1 antibody

Western Blot: Use at 2-5 ug/ml

Product References and Citations for anti-TIE-1 antibody

1. Partanen J and DJ Dumont (1999) Curr Top Microbiol Immunol 237:159. 2. Takakura N et al, (1998) Immunity 9:677. 3. Procopio W et al, (1999) J Biol Chem 274:30196. 4. Sato et al., PNAS 90:9355, 1993 5. Gale et al., Gen Dev 13:1055, 1999

Other Notes

Small volumes of anti-TIE-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TIE-1 purchase

MBS691060 is an antibody targeting TIE-1. Also known as Rabbit Anti-Mouse TIE-1. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TIE-1. It may not necessarily be applicable to this product.

NCBI GI #

144446133

NCBI GeneID

21846

NCBI Accession #

NP_035172

UniProt Primary Accession #

Q06806

UniProt Secondary Accession #

Q811F4; Q8BGI2

UniProt Related Accession #

Q06806

GenBank Nucleotide #

NM_011587.2

NCBI Official Full Name

tyrosine-protein kinase receptor Tie-1

NCBI Official Synonym Full Names

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

NCBI Official Symbol

Tie1

NCBI Official Synonym Symbols

TIE; tie-1; D430008P04Rik

UniProt Protein Name

Tyrosine-protein kinase receptor Tie-1

Protein Family

Tyrosine-protein kinase receptor

UniProt Gene Name

Tie1

UniProt Synonym Gene Names

Tie; Tie-1

UniProt Entry Name

TIE1_MOUSE

NCBI Protein Information

tyrosine-protein kinase receptor Tie-1; tyrosine kinase receptor 1

UniProt Comments for TIE-1

Function: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis

By similarity.

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure: Heterodimer with TEK/TIE2

By similarity.

Subcellular location: Cell membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Specifically expressed in developing vascular endothelial cells. Abundantly expressed in lung and heart, moderately in brain, liver and kidney, and weakly in thymus, spleen and testis. Ref.3

Post-translational modification: Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2

By similarity.

Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.Contains 3 EGF-like domains.Contains 3 fibronectin type-III domains.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain.

Research Articles on TIE-1

1. Shear stress conditions that modulate atherogenic events also regulate Tie1 expression. Therefore, Tie1 may play a novel proinflammatory role in atherosclerosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TIE-1 antibody

Products by Pathway	Pathway Diagram
XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies	XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram

Diseases associated with anti-TIE-1 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>28 publications with TIE-1 and Neoplasms
Inflammation Antibodies	>7 publications with TIE-1 and Inflammation
Hemorrhage Antibodies	>7 publications with TIE-1 and Hemorrhage
Edema Antibodies	>6 publications with TIE-1 and Edema
Necrosis Antibodies	>6 publications with TIE-1 and Necrosis
Liver Neoplasms Antibodies	>4 publications with TIE-1 and Liver Neoplasms
Brain Diseases Antibodies	>4 publications with TIE-1 and Brain Diseases
Respiratory Tract Diseases Antibodies	>3 publications with TIE-1 and Respiratory Tract Diseases
Bone Diseases Antibodies	>2 publications with TIE-1 and Bone Diseases
Kidney Diseases Antibodies	>2 publications with TIE-1 and Kidney Diseases

Organs/Tissues associated with anti-TIE-1 antibody

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>38 publications with TIE-1 and Embryonic Tissue
Heart Antibodies	>21 publications with TIE-1 and Heart
Bone Antibodies	>11 publications with TIE-1 and Bone
Liver Antibodies	>10 publications with TIE-1 and Liver
Kidney Antibodies	>9 publications with TIE-1 and Kidney
Lung Antibodies	>9 publications with TIE-1 and Lung
Skin Antibodies	>8 publications with TIE-1 and Skin
Brain Antibodies	>7 publications with TIE-1 and Brain
Bone Marrow Antibodies	>7 publications with TIE-1 and Bone Marrow
Joint Antibodies	>6 publications with TIE-1 and Joint