Endocan/ESM-1 (ESM-1) Antibody – Rabbit Polyclonal

Endocan, also known as endothelialcell specific molecule1 (ESM1), is a secreted cysteine-rich dermatan sulfate (DS) proteoglycan primarily expressed by endothelial cells within the vascular capillary network in kidney and in the alveolar walls of the lung. Endocan expression has also been detected in different epithelia and in adipocytes. The expression of endocan is upregulated by TNFalpha, IL1beta or lipopolysaccharide and downregulated by IFNgamma. The human Endocan gene encodes a 184 amino acid (aa) residues precursor protein with a 19 aa hydrophobic signal peptide and a 165 aa mature region with 18 Cysteine residues. The DS chain is covalently attached to serine 137. Endocan has been shown to bind CD11a/CD18 integrin (also known as lymphocyte functionassociated antigen1, LFA1) on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM1 and reducing LFA1mediated leukocyte activation. Endocanbinds via its DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity (3, 6). Genetically engineered cells overexpressing endocan has been shown to induce tumor formation, suggesting that Endocan may be involved in the pathophysiology of tumor growth in vivo. Circulating Endocan can be detected in the serum from healthy subjects. In patients with lung cancer or acute and severe sepsis, elevated Endocan concentrations have been reported.

1. Lassalle P et al, J Biol Chem 271:20458, 1996 2. Bechard D et al, J Vasc Res 37:417, 2000 3. Wellner M et al, Horm Metab Res 35:217, 2003 4. Bechard D et al, J Biol Chem 276:48341, 2001 5. Bechard D et al, J Immunol 167:3099, 2001 6. Scherpereel A et al, Cancer Res 63:6084, 2003

Small volumes of anti-ESM-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS691063 is an antibody targeting ESM-1. Also known as Rabbit Anti-Human Endocan/ESM-1. Reactive in Human. Host: Rabbit.