TWEAK Antibody – Goat Polyclonal

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

Function: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. Ref.7 Ref.10

Subunit structure: Homotrimer

Probable. Interacts with the angiogenic factor AGGF1/VG5Q. Ref.8 Ref.10

Subcellular location: Cell membrane; Single-pass type II membrane protein Ref.3. Tumor necrosis factor ligand superfamily member 12, secreted form: Secreted Ref.3. Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein Ref.3.

Tissue specificity: Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.

Post-translational modification: The soluble form derives from the membrane form by proteolytic processing.

Sequence similarities: Belongs to the tumor necrosis factor family.

Sequence caution: The sequence AAH19047.1 differs from that shown. Reason: Frameshift at position 125.