Rabbit Anti-OSM Polyclonal Antibody – Cat# MBS691194

Oncostatin M (OSM) Antibody – Rabbit Polyclonal

Name: OSM Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS691194
Price: 605 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691194

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi\'s sarcoma cells, OSH can exert both stimulatory and inhibitory… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Oncostatin M (OSM), Polyclonal Antibody

Full Product Name

Rabbit Anti-Human Oncostatin M

Product Gene Name

anti-OSM antibody

Product Synonym Names

Antigen-Affinity Purified Polyclonal Antibodies Anti-human Oncostatin-M

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

Affinity chromatography

Molecular Weight

28,484 Da

Chromosome Location

Chromosome: 22; NC_000022.11 (30262828..30266840, complement). Location: 22q12.2

OMIM

165095

3D Structure

ModBase 3D Structure for P13725

Antibody Generation

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant human Oncostatin M. Anti-human Oncostatin M specific antibody was purified by affinity chromatography employing immobilized human Oncostatin M matrix.

Buffer

PBS; pH 7.2

Neutralization

To yield one-half maximal inhibition [ND50] of the biological activity of human Oncostatin-M (10 ng/ml), a concentration of 0.100 - 0.175 g/ml of this antibody is required.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-OSM antibody

ELISA (EIA), Western Blot (WB), Neutr

Application Notes for anti-OSM antibody

Western Blot: To detect human Oncostatin-M by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 g/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant human Oncostatin-M is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-OSM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OSM purchase

MBS691194 is an antibody targeting OSM. Also known as Rabbit Anti-Human Oncostatin M. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OSM. It may not necessarily be applicable to this product.

NCBI GI #

10092621

NCBI GeneID

5008

NCBI Accession #

NP_065391.1

UniProt Primary Accession #

P13725

UniProt Secondary Accession #

Q6FHP8; Q9UCP6

UniProt Related Accession #

P13725

GenBank Nucleotide #

NM_020530.4

NCBI Official Full Name

oncostatin-M preproprotein

NCBI Official Synonym Full Names

oncostatin M

NCBI Official Symbol

OSM

UniProt Protein Name

Oncostatin-M

Protein Family

Oncostatin

UniProt Gene Name

OSM

UniProt Synonym Gene Names

OSM

UniProt Entry Name

ONCM_HUMAN

NCBI Protein Information

oncostatin-M

NCBI Summary for OSM

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq, Jul 2008]

UniProt Comments for OSM

Function: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration

By similarity. Ref.8 Ref.12

Subcellular location: Secreted.

Post-translational modification: Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.

Sequence similarities: Belongs to the LIF/OSM family.

Research Articles on OSM

1. TGFBI and periostin, extracellular matrix proteins implicated in tumorigenesis and metastasis, were identified as oncostatin M-induced secreted proteins in mesenchymal stem cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OSM antibody

Reference Product	PubMed Publications
LIFR antibody	>386 publications with OSM and LIFR
STAT3 antibody	>227 publications with OSM and STAT3
IL6ST antibody	>176 publications with OSM and IL6ST
STAT1 antibody	>74 publications with OSM and STAT1
OSMR antibody	>61 publications with OSM and OSMR
SOCS3 antibody	>29 publications with OSM and SOCS3
IL3 antibody	>2 publications with OSM and IL3
MMP1 antibody	>2 publications with OSM and MMP1

Pathways associated with anti-OSM antibody

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Oncostatin M Signaling Pathway antibodies	Oncostatin M Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram

Diseases associated with anti-OSM antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>333 publications with OSM and Neoplasms
Inflammation Antibodies	>194 publications with OSM and Inflammation
Necrosis Antibodies	>149 publications with OSM and Necrosis
Liver Diseases Antibodies	>65 publications with OSM and Liver Diseases
Disease Models, Animal Antibodies	>64 publications with OSM and Disease Models, Animal
Brain Diseases Antibodies	>62 publications with OSM and Brain Diseases
Kidney Diseases Antibodies	>52 publications with OSM and Kidney Diseases
Breast Neoplasms Antibodies	>41 publications with OSM and Breast Neoplasms
Lung Diseases Antibodies	>37 publications with OSM and Lung Diseases
Carcinoma, Hepatocellular Antibodies	>37 publications with OSM and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-OSM antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>446 publications with OSM and Blood
Kidney Antibodies	>125 publications with OSM and Kidney
Lung Antibodies	>95 publications with OSM and Lung
Intestine Antibodies	>20 publications with OSM and Intestine
Thymus Antibodies	>17 publications with OSM and Thymus
Ovary Antibodies	>14 publications with OSM and Ovary
Uncharacterized Tissue Antibodies	>2 publications with OSM and Uncharacterized Tissue