Goat Anti-LEC/NCC-4 Polyclonal Antibody – Cat# MBS691231

LEC/NCC-4 Antibody – Goat Polyclonal

Name: LEC/NCC-4 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS691231
Price: 605 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691231

LEC or NCC-4 is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

LEC/NCC-4, Polyclonal Antibody

Full Product Name

Goat Anti-Human LEC/NCC-4

Product Gene Name

anti-LEC/NCC-4 antibody

Product Synonym Names

Antigen-Affinity Purified Polyclonal Antibodies Anti-human LEC/NCC-4

Clonality

Polyclonal

Host

Goat

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

Affinity chromatography

Molecular Weight

13,600 Da

Chromosome Location

Chromosome: 17; NC_000017.11 (35976493..35982360, complement). Location: 17q11.2

OMIM

601394

3D Structure

ModBase 3D Structure for O15467

Antibody Generation

Produced from sera of goats pre-immunized with highly pure (>98%) recombinant human LEC (human Liver-Expressed Chemokine). Anti-human LEC specific antibody was purified by affinity chromatography employing immobilized human LEC matrix.

Buffer

PBS; pH 7.2

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-LEC/NCC-4 antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-LEC/NCC-4 antibody

Western Blot: To detect LEC by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant LEC is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-LEC/NCC-4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LEC/NCC-4 purchase

MBS691231 is an antibody targeting LEC/NCC-4. Also known as Goat Anti-Human LEC/NCC-4. Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for LEC/NCC-4. It may not necessarily be applicable to this product.

NCBI GI #

4759074

NCBI GeneID

6360

NCBI Accession #

NP_004581.1

UniProt Primary Accession #

O15467

UniProt Secondary Accession #

Q4KKU0

UniProt Related Accession #

O15467

GenBank Nucleotide #

NM_004590.2

NCBI Official Full Name

C-C motif chemokine 16

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 16

NCBI Official Symbol

CCL16

NCBI Official Synonym Symbols

LEC; LMC; NCC4; CKb12; HCC-4; LCC-1; Mtn-1; NCC-4; SCYL4; ILINCK; SCYA16

UniProt Protein Name

C-C motif chemokine 16

UniProt Synonym Protein Names

Chemokine CC-4; HCC-4; Chemokine LEC; IL-10-inducible chemokine; LCC-1; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; LMC; Monotactin-1; MTN-1; NCC-4; Small-inducible cytokine A16

UniProt Gene Name

CCL16

UniProt Synonym Gene Names

ILINCK; NCC4; SCYA16; HCC-4; LMC; MTN-1

UniProt Entry Name

CCL16_HUMAN

NCBI Protein Information

C-C motif chemokine 16; monotactin-1; chemokine LEC; chemokine CC-4; new CC chemokine 4; liver CC chemokine-1; IL-10-inducible chemokine; liver-expressed chemokine; small-inducible cytokine A16; lymphocyte and monocyte chemoattractant; small inducible cytokine subfamily A (Cys-Cys), member 16

NCBI Summary for LEC/NCC-4

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]

UniProt Comments for LEC/NCC-4

Function: Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

Subcellular location: Secreted.

Tissue specificity: Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

Induction: By IL10/interleukin-10.

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.

Research Articles on LEC/NCC-4

1. High umbilical artery CCL16 is prominently detected in preterm preeclamptic pregnancies with severe growth restriction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LEC/NCC-4 antibody

Reference Product	PubMed Publications
CCR1 antibody	>17 publications with LEC/NCC-4 and CCR1
CCR8 antibody	>8 publications with LEC/NCC-4 and CCR8
CCR2 antibody	>7 publications with LEC/NCC-4 and CCR2
CCR5 antibody	>7 publications with LEC/NCC-4 and CCR5
CCR3 antibody	>4 publications with LEC/NCC-4 and CCR3
CXCL11 antibody	>3 publications with LEC/NCC-4 and CXCL11
CXCL13 antibody	>1 publications with LEC/NCC-4 and CXCL13
HRH4 antibody	>1 publications with LEC/NCC-4 and HRH4

Pathways associated with anti-LEC/NCC-4 antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with anti-LEC/NCC-4 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>11 publications with LEC/NCC-4 and Neoplasms
Inflammation Antibodies	>9 publications with LEC/NCC-4 and Inflammation
Neoplasms, Experimental Antibodies	>7 publications with LEC/NCC-4 and Neoplasms, Experimental
Disease Models, Animal Antibodies	>5 publications with LEC/NCC-4 and Disease Models, Animal
Adenocarcinoma Antibodies	>4 publications with LEC/NCC-4 and Adenocarcinoma
Mammary Neoplasms, Animal Antibodies	>3 publications with LEC/NCC-4 and Mammary Neoplasms, Animal
Liver Diseases Antibodies	>2 publications with LEC/NCC-4 and Liver Diseases
Lung Neoplasms Antibodies	>2 publications with LEC/NCC-4 and Lung Neoplasms
Kidney Diseases Antibodies	>1 publications with LEC/NCC-4 and Kidney Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with LEC/NCC-4 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-LEC/NCC-4 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>11 publications with LEC/NCC-4 and Liver