Rabbit Anti-VEGF-D Polyclonal Antibody – Cat# MBS691245

VEGF-D Antibody – Rabbit Polyclonal

Name: VEGF-D Antibody; Polyclonal; Rabbit; Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS691245
Price: 510 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691245

Vascular endothelial growth factor D (VEGF-D), also known as C-fos induced growth factor (FIGF), is a vascular endothelial growth factor. This secreted protein is a member of the platelet derived growth factor/vascular endothelial growth factor (PDGF/VEGF)… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

VEGF-D, Polyclonal Antibody

Full Product Name

Rabbit Anti-Rat VEGF-D

Product Gene Name

anti-VEGF-D antibody

Product Synonym Names

Anti-rat Vascular Endothelial Growth Factor-D; c-Fos-induced growth factor; Figf

Clonality

Polyclonal

Clone Number

Rabbit IgG

Host

Rabbit

Species Reactivity

Rat

Form/Format

Lyophilized

Purity/Purification

Protein A purified

Preparation and Storage

The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 degree C. Frozen aliquots are stable for at least 6 months when stored at -20 degree C.

Molecular Weight

37,113 Da

Chromosome Location

Chromosome: X; NC_005120.3 (32190233..32225843, complement). Location: Xq31

3D Structure

ModBase 3D Structure for O35251

Immunogen

N-terminal peptide

Preparation

Produced from sera of rabbits pre-immunized with a N-terminal peptide of rat dNdC-VEGF-D.

Buffer

PBS

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-VEGF-D antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-VEGF-D antibody

Western Blot: Use 2-5 ug/ml ELISA: Use at 2-5 ug/ml

Product References and Citations for anti-VEGF-D antibody

1. Orlandini, M. et al. (1996) Proc. Natl. Acad. Sci. USA 93:11675. 2. Stacker, S.A. et al. (1999) J. Biol. Chem. 274:32127. 3. McColl, B.K. et al. (2007) FASEB J. 21:1088. 4. Baldwin, M.E. et al. (2001) J. Biol. Chem. 276:44307. 5. Baldwin, M.E. et al. (2001) J. Biol. Chem. 276:19166. 6. Karpanen, T. et al. (2006) Am. J. Pathol. 169:708. 7. Orlandini, M. et al. (2006) J. Biol. Chem. 281:17961. 8. Stacker, S.A. et al. (2001) Nature Med. 7:186. 9. Karpanen, T. et al. (2006) FASEB J. 20:1462.

Other Notes

Small volumes of anti-VEGF-D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VEGF-D purchase

MBS691245 is an antibody targeting VEGF-D. Also known as Rabbit Anti-Rat VEGF-D. Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for VEGF-D. It may not necessarily be applicable to this product.

NCBI GI #

13929074

NCBI GeneID

360457

NCBI Accession #

NP_113949.1

UniProt Primary Accession #

O35251

UniProt Secondary Accession #

Q91ZE4

UniProt Related Accession #

O35251

GenBank Nucleotide #

NM_0371761.1

NCBI Official Full Name

vascular endothelial growth factor D

NCBI Official Synonym Full Names

c-fos induced growth factor

NCBI Official Symbol

Figf

NCBI Official Synonym Symbols

Vegf-d

UniProt Protein Name

Vascular endothelial growth factor D

UniProt Synonym Protein Names

c-Fos-induced growth factor

Protein Family

Vascular endothelial growth factor

UniProt Gene Name

Figf

UniProt Synonym Gene Names

Vegfd; VEGF-D; FIGF

UniProt Entry Name

VEGFD_RAT

NCBI Protein Information

vascular endothelial growth factor D; c-fos-induced growth factor

NCBI Summary for VEGF-D

binds to and activates the tyrosine kinase receptor VEGFR-3 and VEGFR-2; involved in positive regulation of lymphatic blood vessel growth [RGD, Feb 2006]

UniProt Comments for VEGF-D

Function: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-3 (Flt4) receptor

By similarity.

Subunit structure: Homodimer; non-covalent and antiparallel

By similarity.

Subcellular location: Secreted

By similarity.

Tissue specificity: Highly expressed in the spleen, kidney, lung, tongue, ovary and mammary gland. Ref.1

Post-translational modification: Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions

By similarity.

Miscellaneous: Indolinones; MAE87, MAE106 and MAZ51 inhibit VEGF-D induced activation of VEGFR-3.

Sequence similarities: Belongs to the PDGF/VEGF growth factor family.

Research Articles on VEGF-D

1. Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-VEGF-D antibody

Reference Product	PubMed Publications
Vegfa antibody	>7 publications with VEGF-D and Vegfa
Vegfc antibody	>7 publications with VEGF-D and Vegfc
Flt4 antibody	>5 publications with VEGF-D and Flt4
Flt1 antibody	>4 publications with VEGF-D and Flt1
Vwf antibody	>2 publications with VEGF-D and Vwf

Pathways associated with anti-VEGF-D antibody

Products by Pathway	Pathway Diagram
Cardiovascular Signaling Pathway antibodies	Cardiovascular Signaling Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
Pathways In Cancer antibodies	Pathways In Cancer Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram

Diseases associated with anti-VEGF-D antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>3 publications with VEGF-D and Nervous System Diseases
Breast Neoplasms Antibodies	>3 publications with VEGF-D and Breast Neoplasms
Inflammation Antibodies	>3 publications with VEGF-D and Inflammation
Mammary Neoplasms, Animal Antibodies	>2 publications with VEGF-D and Mammary Neoplasms, Animal
Lung Neoplasms Antibodies	>2 publications with VEGF-D and Lung Neoplasms
Weight Gain Antibodies	>1 publications with VEGF-D and Weight Gain
Prenatal Exposure Delayed Effects Antibodies	>1 publications with VEGF-D and Prenatal Exposure Delayed Effects
Kidney Diseases Antibodies	>1 publications with VEGF-D and Kidney Diseases
Insulin Resistance Antibodies	>1 publications with VEGF-D and Insulin Resistance
Hyperglycemia Antibodies	>1 publications with VEGF-D and Hyperglycemia

Organs/Tissues associated with anti-VEGF-D antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>4 publications with VEGF-D and Kidney