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IL-2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691250

Interleukin 2 (IL-2) was initially identified as a T cell growth factor that is produced by T cells following activation by mitogens or antigens. Since then, it has also been shown to stimulate the growth and differentiation of B cells, natural killer (NK)… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IL-2, Polyclonal Antibody
Full Product Name
Goat Anti-Human IL-2
Product Gene Name
Product Synonym Names
Antigen-Affinity Purified Polyclonal Antibodies Anti-human IL-2
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Affinity chromatography
Molecular Weight
17,628 Da
Chromosome Location
Chromosome: 4; NC_000004.12 (122451470..122456495, complement). Location: 4q26-q27
OMIM
147680
3D Structure
ModBase 3D Structure for P60568
Antibody Generation
Produced from sera of goats pre-immunized with highly pure (>98%) recombinant hIL-20 (human Interleukin-20). Anti-hIL 20 specific antibody was purified by affinity chromatography employing immobilized hIL-20 matrix.
Buffer
PBS; pH 7.2
Neutralization
To yield one-half maximal inhibition [ND50] of the biological activity of human IL-2 (2.0 ng/ml), a concentration of 0.12 - 0.16 ìg/ml of this antibody is required
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-IL-2 antibody
ELISA (EIA), Western Blot (WB), Neutr
Application Notes for anti-IL-2 antibody
Western Blot: To detect human IL-2 by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ìg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant human IL-2 is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions

Other Notes

Small volumes of anti-IL-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-2 purchase

MBS691250 is an antibody targeting IL-2. Also known as Goat Anti-Human IL-2. Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interleukin-2
NCBI Official Synonym Full Names
interleukin 2
NCBI Official Symbol
IL2
NCBI Official Synonym Symbols
IL-2; TCGF; lymphokine
UniProt Protein Name
Interleukin-2
UniProt Synonym Protein Names
T-cell growth factor
UniProt Gene Name
IL2
UniProt Synonym Gene Names
IL-2; TCGF
UniProt Entry Name
IL2_HUMAN
NCBI Protein Information
interleukin-2; aldesleukin; T cell growth factor; involved in regulation of T-cell clonal expansion

NCBI Summary for IL-2

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL-2

Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Subcellular location: Secreted.

Involvement in disease: A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Pharmaceutical use: Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.

Sequence similarities: Belongs to the IL-2 family.

Sequence caution: The sequence AAA59140.1 differs from that shown. Reason: Erroneous initiation.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-IL-2 antibody

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