4-1BB receptor Antibody – Goat Polyclonal

4-1BB (or human 4-1BBL receptor) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is alternatively known as TNFR-SF9, CD137, and ILA. The 255 amino acid is a type I transmembrane protein having in its extracellular domain four of the cysteine-rich motifs that are characteristic of the TNF receptor superfamily. The 30 kDa glycoprotein exists both as a monomer and as a dimer on T cells. The human and mouse proteins share 60% amino acid identity. 4-1BB is absent from naive T cells, but it is upregulated and continually expressed following T cell activation. The natural ligand, 4-1BBL, is a member of the TNF superfamily and is expressed on activated antigen presenting cells including dendritic cells, macrophages, and B cells. Crosslinking of 4-1BB by 4-1BBL or by agonistic antibodies transmits a potent co stimulatory signal that enhances the effect of other activating signals such as PHA or antiCD3 antibodies. 4-1BB signals through the TFAF2NIK pathway resulting in activation of NFkappaB and ultimately promoting proliferation and survival of T cells.

Small volumes of anti-4-1BB receptor antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS691262 is an antibody targeting 4-1BB receptor. Also known as Goat Anti-Human 4-1BB receptor. Reactive in Human. Host: Goat.