Rabbit Anti-IFN-gamma Polyclonal Antibody – Cat# MBS691270

IFN-gamma Antibody – Rabbit Polyclonal

Name: IFN-gamma Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS691270
Price: 605 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691270

IFN-gamma is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-gamma receptors are present in most immune cells, which respond to IFN-gamma signaling by increasing the surface expression of class I MHC… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IFN-gamma, Polyclonal Antibody

Full Product Name

Rabbit Anti-Mouse IFN-gamma

Product Gene Name

anti-IFN-gamma antibody

Product Synonym Names

Antigen-Affinity Purified Polyclonal Antibodies Anti-murine IFN-gamma

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Lyophilized

Purity/Purification

Protein A chromatography

Molecular Weight

17,907 Da

Chromosome Location

Chromosome: 10; NC_000076.6 (118441047..118445892). Location: 10 D2; 10 66.75 cM

3D Structure

ModBase 3D Structure for P01580

Antibody Generation

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant murine IFN-gamma (murine Interferon-gamma). Anti-murine IFN-gamma specific antibody was purified by affinity chromatography employing immobilized murine IFN-gamma matrix.

Buffer

PBS; pH 7.2

Neutralization

To yield one-half maximal inhibition [ND50] of the biological activity of hIFN-gamma (50 pg/ml), a concentration of 0.04 - 0.06 ng/ml of this antibody is required.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-IFN-gamma antibody

ELISA (EIA), Western Blot (WB), Neutr

Application Notes for anti-IFN-gamma antibody

Western Blot: To detect murine IFN-gamma by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 g/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant murine IFN-gamma is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-IFN-gamma antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFN-gamma purchase

MBS691270 is an antibody targeting IFN-gamma. Also known as Rabbit Anti-Mouse IFN-gamma. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IFN-gamma. It may not necessarily be applicable to this product.

NCBI GI #

33468859

NCBI GeneID

15978

NCBI Accession #

NP_032363.1

UniProt Primary Accession #

P01580

UniProt Secondary Accession #

Q542B8

UniProt Related Accession #

P01580

GenBank Nucleotide #

NM_008337.3

NCBI Official Full Name

interferon gamma

NCBI Official Synonym Full Names

interferon gamma

NCBI Official Symbol

Ifng

NCBI Official Synonym Symbols

Ifg; IFN-g

UniProt Protein Name

Interferon gamma

Protein Family

Interferon gamma receptor

UniProt Gene Name

Ifng

UniProt Synonym Gene Names

IFN-gamma

UniProt Entry Name

IFNG_MOUSE

NCBI Protein Information

interferon gamma; IFN-gamma; gamma interferon

NCBI Summary for IFN-gamma

This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of the both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial inflections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Sep 2015]

UniProt Comments for IFN-gamma

Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

Subunit structure: Homodimer.

Subcellular location: Secreted.

Tissue specificity: Released primarily from activated T lymphocytes.

Sequence similarities: Belongs to the type II (or gamma) interferon family.

Research Articles on IFN-gamma

1. Activated iNKT cells rapidly release IL-4, which promotes neutrophil survival and hepatitis but also sequentially produce IFN-gamma, which acts in a negative feedback loop to ameliorate iNKT hepatitis by inducing neutrophil apoptosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IFN-gamma antibody

Reference Product	PubMed Publications
Il4 antibody	>74 publications with IFN-gamma and Il4
Il6 antibody	>68 publications with IFN-gamma and Il6
Il2 antibody	>45 publications with IFN-gamma and Il2
Stat1 antibody	>31 publications with IFN-gamma and Stat1
Ifngr1 antibody	>25 publications with IFN-gamma and Ifngr1
Il18 antibody	>21 publications with IFN-gamma and Il18
Irf1 antibody	>16 publications with IFN-gamma and Irf1
Socs1 antibody	>8 publications with IFN-gamma and Socs1
Jak2 antibody	>3 publications with IFN-gamma and Jak2
Jak1 antibody	>3 publications with IFN-gamma and Jak1

Pathways associated with anti-IFN-gamma antibody

Products by Pathway	Pathway Diagram
African Trypanosomiasis Pathway antibodies	African Trypanosomiasis Pathway Diagram
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Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram

Diseases associated with anti-IFN-gamma antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>113 publications with IFN-gamma and Necrosis
Autoimmune Diseases Antibodies	>75 publications with IFN-gamma and Autoimmune Diseases
Respiratory Tract Diseases Antibodies	>56 publications with IFN-gamma and Respiratory Tract Diseases
Hepatitis Antibodies	>26 publications with IFN-gamma and Hepatitis
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO Antibodies	>21 publications with IFN-gamma and MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO
Lymphoproliferative Disorders Antibodies	>17 publications with IFN-gamma and Lymphoproliferative Disorders
Diabetes Mellitus, Type 1 Antibodies	>15 publications with IFN-gamma and Diabetes Mellitus, Type 1
HIV Infections Antibodies	>13 publications with IFN-gamma and HIV Infections
Arthritis, Rheumatoid Antibodies	>12 publications with IFN-gamma and Arthritis, Rheumatoid
Hepatitis C Antibodies	>11 publications with IFN-gamma and Hepatitis C

Organs/Tissues associated with anti-IFN-gamma antibody

Organ/Tissue Name	Pubmed Publications
Spleen Antibodies	>34 publications with IFN-gamma and Spleen
Mixed Antibodies	>11 publications with IFN-gamma and Mixed
Embryonic Tissue Antibodies	>8 publications with IFN-gamma and Embryonic Tissue