Rabbit Anti-IP-10 Polyclonal Antibody – Cat# MBS691373

IP-10 Antibody – Rabbit Polyclonal

Name: IP-10 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS691373
Price: 605 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691373

Chemokine (C-X-C motif) ligand 10 (CXCL10) is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa interferon-gamma-induced protein (?-IP10 or IP-10). CXCL10 is secreted by several cell types in response to IFN-?. These cell… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IP-10, Polyclonal Antibody

Full Product Name

Rabbit Anti-Mouse IP-10

Product Gene Name

anti-IP-10 antibody

Product Synonym Names

Antigen-Affinity Purified Polyclonal Antibodies Anti-murine Interleukin-10

Clonality

Polyclonal

Isotype

Rabbit IgG

Host

Rabbit

Species Reactivity

Species Reactivity: Mouse
Cross reactivity: Mouse

Form/Format

Lyophilized from PBS, pH 7.2

Purity/Purification

Antigen-affinity purified

Preparation and Storage

The lyophilized antibody is stable for 5 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2°C to 8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. Avoid repeated freeze and thaw cycles.

Chromosome Location

Chromosome: 5; NC_000071.6 (92346638..92348889, complement). Location: 5 E2; 5 46.57 cM

3D Structure

ModBase 3D Structure for P17515

Immunogen

Recombinant mouse IP-10

Reconstitution buffer

Water

Reconstitution

Centrifuge vial prior to opening. Reconstitute the antibody in sterile water to a concentration of 0.1 - 1.0 mg/ml

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-IP-10 antibody

Immunostaining, Neutralization, ELISA (EIA), Western Blot (WB)

Application Notes for anti-IP-10 antibody

- Immunostaining: This antibody stained colchicine injected mouse brain tissue (including the hippocampus region). The primary antibody was incubated at 1 ug/ml overnight at 4°C. This was followed by a peroxidase conjugated secondary antibody and then a fluorescein Tyramide Signal Amplification (TSATM) reagent. Optimal concentrations and conditions may vary.
- Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of mIP-10 (100 ng/ml), a concentration of 10 ug/ml of this antibody is required.
- ELISA: To detect murine IP-10 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of at least 0.5 – 2 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with compatible secondary reagents, allows the detection of 0.2 - 0.4 ng/well of recombinant murine IP-10.
- Western Blot: To detect murine IP-10 by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant murine IP-10 is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Optimal Dilutions should be determined by each laboratory for each application!

Other Notes

Small volumes of anti-IP-10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IP-10 purchase

MBS691373 is an antibody targeting IP-10. Also known as Rabbit Anti-Mouse IP-10. Reactive in Species Reactivity: Mouse
Cross reactivity: Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IP-10. It may not necessarily be applicable to this product.

NCBI GI #

10946576

NCBI GeneID

15945

NCBI Accession #

NP_067249.1

UniProt Primary Accession #

P17515

UniProt Related Accession #

P17515

GenBank Nucleotide #

NM_021274.2

NCBI Official Full Name

C-X-C motif chemokine 10

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 10

NCBI Official Symbol

Cxcl10

NCBI Official Synonym Symbols

C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10

UniProt Protein Name

C-X-C motif chemokine 10

UniProt Synonym Protein Names

10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; C7; Interferon-gamma induced protein CRG-2; Small-inducible cytokine B10

UniProt Gene Name

Cxcl10

UniProt Synonym Gene Names

Crg2; Ifi10; Inp10; Scyb10; Gamma-IP10; IP-10

UniProt Entry Name

CXL10_MOUSE

NCBI Protein Information

C-X-C motif chemokine 10; gamma-IP10; interferon activated gene 10; small-inducible cytokine B10; interferon-gamma induced protein CRG-2; interferon-gamma-induced protein CRG-2; 10 kDa interferon gamma-induced protein; small inducible cytokine B subfamily (Cys-X-Cys), member 10

UniProt Comments for IP-10

Function: In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.

Subcellular location: Secreted.

Tissue specificity: Expressed in the spleen, thymus, lymph nodes and liver. Ref.5

Induction: By interferon gamma.

Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.

Research Articles on IP-10

1. Data indicate that ginsenoside Rg1 (Rg1) reduced ICAM-1 and CXCL-10 mRNA expression as well as the number of CD4(+) and CD8(+) T lymphocytes infiltrating in the liver.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IP-10 antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with anti-IP-10 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>993 publications with IP-10 and Inflammation
Necrosis Antibodies	>594 publications with IP-10 and Necrosis
Neoplasms Antibodies	>404 publications with IP-10 and Neoplasms
Lung Diseases Antibodies	>287 publications with IP-10 and Lung Diseases
Liver Diseases Antibodies	>189 publications with IP-10 and Liver Diseases
Cardiovascular Diseases Antibodies	>147 publications with IP-10 and Cardiovascular Diseases
Fibrosis Antibodies	>109 publications with IP-10 and Fibrosis
Neoplasms, Experimental Antibodies	>103 publications with IP-10 and Neoplasms, Experimental
Kidney Diseases Antibodies	>77 publications with IP-10 and Kidney Diseases
Pneumonia Antibodies	>52 publications with IP-10 and Pneumonia

Organs/Tissues associated with anti-IP-10 antibody

Organ/Tissue Name	Pubmed Publications
Lymph Node Antibodies	>147 publications with IP-10 and Lymph Node
Spleen Antibodies	>121 publications with IP-10 and Spleen
Bone Marrow Antibodies	>115 publications with IP-10 and Bone Marrow
Eye Antibodies	>81 publications with IP-10 and Eye
Intestine Antibodies	>79 publications with IP-10 and Intestine
Thymus Antibodies	>52 publications with IP-10 and Thymus
Embryonic Tissue Antibodies	>49 publications with IP-10 and Embryonic Tissue
Mammary Gland Antibodies	>7 publications with IP-10 and Mammary Gland
Epididymis Antibodies	>1 publications with IP-10 and Epididymis