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FGF-7/KGF Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691434

Keratinocyte Growth Factor (KGF/FGF-7) is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of variety of tissues, by promoting cellular proliferation and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
FGF-7/KGF, Polyclonal Antibody
Full Product Name
Rabbit Anti-Human FGF-7/KGF
Product Gene Name
Product Synonym Names
Antigen-Affinity Purified Polyclonal Antibodies Anti-human KGF/FGF-7
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Affinity chromatography
Molecular Weight
22,509 Da
Chromosome Location
Chromosome: 15; NC_000015.10 (49423178..49487326). Location: 15q21.2
OMIM
148180
3D Structure
ModBase 3D Structure for P21781
Antibody Generation
Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant human KGF (hKGF). Anti-human FGF-7 (KGF) specific antibody was purified by affinity chromatography employing immobilized human KGF matrix.
Buffer
PBS; pH 7.2
Neutralization
To yield one-half maximal inhibition [ND50]of the biological activity of hKGF (25 ng/ml), a concentration of 0.56-0.85 ìg/ml of this antibody is required.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-FGF-7/KGF antibody
ELISA (EIA), Western Blot (WB), Neutr
Application Notes for anti-FGF-7/KGF antibody
Western Blot: To detect hKGF by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ìg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hKGF is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions

Other Notes

Small volumes of anti-FGF-7/KGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGF-7/KGF purchase

MBS691434 is an antibody targeting FGF-7/KGF. Also known as Rabbit Anti-Human FGF-7/KGF. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF-7/KGF. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
fibroblast growth factor 7
NCBI Official Synonym Full Names
fibroblast growth factor 7
NCBI Official Symbol
FGF7
NCBI Official Synonym Symbols
KGF; HBGF-7
UniProt Protein Name
Fibroblast growth factor 7
UniProt Synonym Protein Names
Heparin-binding growth factor 7; HBGF-7; Keratinocyte growth factor
UniProt Gene Name
FGF7
UniProt Synonym Gene Names
KGF; FGF-7; HBGF-7
UniProt Entry Name
FGF7_HUMAN
NCBI Protein Information
fibroblast growth factor 7; FGF-7; keratinocyte growth factor; heparin-binding growth factor 7

NCBI Summary for FGF-7/KGF

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]
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UniProt Comments for FGF-7/KGF

Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Ref.4 Ref.6

Subunit structure: Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.4 Ref.5 Ref.6

Subcellular location: Secreted.

Tissue specificity: Epithelial cell.

Sequence similarities: Belongs to the heparin-binding growth factors family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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