Human TNFRSF9 Active Protein – Cat# MBS691495

4-1bb Receptor, Soluble (TNFRSF9) Human Active Protein

Name: TNFRSF9 Active Protein; 4-1bb Receptor, Soluble; Human; MyBioSource
Brand: MyBioSource
SKU: MBS691495
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691495

4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory… More details

$305 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

4-1BB receptor, soluble (TNFRSF9), Active Protein

Full Product Name

Human 4-1BB receptor, soluble (TNFRSF9)

Product Gene Name

TNFRSF9 active protein

Product Synonym Names

Recombinant Human soluble 4-1BB receptor

Sequence

MERTRSLQDP CSNCPAGTFC DNNRNQICSP CPPNSFSSAG GQRTCD ICRQ CKGVFRTRKE CSSTSNAECD CTPGFHCLGA GCSMCEQDCK Q GQELTKKGC KNCCFGTFND QKRGICRPWT NCSLDGKSVL VNGTKER DVV CGPSPADLSP GASSVTPPAP AREPGHS

Host

E Coli

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

> 98% by SDS-PAGE and HPLC analyses

Molecular Weight

17.7 kDa

Chromosome Location

Chromosome: 1; NC_000001.11 (7915871..7943165, complement). Location: 1p36

OMIM

602250

3D Structure

ModBase 3D Structure for Q07011

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 0.1 ng per ìg of 4-1BB receptor

Biological Activity

Determined by its inhibitory effect of the 4-1BBL mediated stimulation of IL-8 production by human PBMC. About 90% of inibition was seen using a concentration of 1ug for both 4-1BBL and 4-1BBR.

Product Categories/Family for TNFRSF9 active protein

Soluble receptors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of TNFRSF9 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF9 purchase

MBS691495 is an active protein targeting TNFRSF9. Also known as Human 4-1BB receptor, soluble (TNFRSF9). Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF9. It may not necessarily be applicable to this product.

NCBI GI #

5730095

NCBI GeneID

3604

NCBI Accession #

NP_001552.2

UniProt Primary Accession #

Q07011

UniProt Related Accession #

Q07011; AAB34924

GenBank Nucleotide #

NM_001561.5

NCBI Official Full Name

tumor necrosis factor receptor superfamily member 9

NCBI Official Synonym Full Names

tumor necrosis factor receptor superfamily, member 9

NCBI Official Symbol

TNFRSF9

NCBI Official Synonym Symbols

ILA; 4-1BB; CD137; CDw137

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 9

UniProt Synonym Protein Names

4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA

Protein Family

Tumor necrosis factor receptor superfamily

UniProt Gene Name

TNFRSF9

UniProt Synonym Gene Names

CD137; ILA

UniProt Entry Name

TNR9_HUMAN

NCBI Protein Information

tumor necrosis factor receptor superfamily member 9; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor; homolog of mouse 4-1BB; receptor protein 4-1BB; T-cell antigen 4-1BB homolog; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63

NCBI Summary for TNFRSF9

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]

UniProt Comments for TNFRSF9

Function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Subunit structure: Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1. Ref.9 Ref.10 Ref.11

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Expressed on the surface of activated T-cells.

Sequence similarities: Contains 4 TNFR-Cys repeats.

Research Articles on TNFRSF9

1. Dengue virus induces CD137 signaling to enhance apoptosis by increasing TNF-alpha production via activation of p38 MAPK.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TNFRSF9 active protein

Reference Product	PubMed Publications
TNFSF9 active protein	>71 publications with TNFRSF9 and TNFSF9
TNFRSF4 active protein	>39 publications with TNFRSF9 and TNFRSF4
TRAF2 active protein	>15 publications with TNFRSF9 and TRAF2
IL2RA active protein	>13 publications with TNFRSF9 and IL2RA
TRAF1 active protein	>8 publications with TNFRSF9 and TRAF1
TRAF3 active protein	>3 publications with TNFRSF9 and TRAF3
IL2RB active protein	>2 publications with TNFRSF9 and IL2RB
IL2RG active protein	>1 publications with TNFRSF9 and IL2RG

Pathways associated with TNFRSF9 active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Downstream Signaling In Naive CD8+ T Cells Pathway antibodies	Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
TCR Signaling Pathway antibodies	TCR Signaling Pathway Diagram

Diseases associated with TNFRSF9 active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>329 publications with TNFRSF9 and Necrosis
Neoplasms Antibodies	>203 publications with TNFRSF9 and Neoplasms
Immune System Diseases Antibodies	>121 publications with TNFRSF9 and Immune System Diseases
Neoplasms, Experimental Antibodies	>65 publications with TNFRSF9 and Neoplasms, Experimental
Inflammation Antibodies	>48 publications with TNFRSF9 and Inflammation
Cardiovascular Diseases Antibodies	>20 publications with TNFRSF9 and Cardiovascular Diseases
Nervous System Diseases Antibodies	>19 publications with TNFRSF9 and Nervous System Diseases
Liver Diseases Antibodies	>18 publications with TNFRSF9 and Liver Diseases
Lung Neoplasms Antibodies	>15 publications with TNFRSF9 and Lung Neoplasms
Liver Neoplasms Antibodies	>13 publications with TNFRSF9 and Liver Neoplasms

Organs/Tissues associated with TNFRSF9 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>471 publications with TNFRSF9 and Blood
Lung Antibodies	>36 publications with TNFRSF9 and Lung
Brain Antibodies	>12 publications with TNFRSF9 and Brain
Intestine Antibodies	>12 publications with TNFRSF9 and Intestine
Kidney Antibodies	>9 publications with TNFRSF9 and Kidney
Pancreas Antibodies	>7 publications with TNFRSF9 and Pancreas
Pharynx Antibodies	>3 publications with TNFRSF9 and Pharynx
Uterus Antibodies	>2 publications with TNFRSF9 and Uterus