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IL-11 Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691518

IL-11 is a multifunctional cytokine produced by stromal cells such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an… More details

$305 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-11, Active Protein
Full Product Name
Human IL-11
Product Gene Name
Product Synonym Names
Recombinant Human IL-11
Sequence
MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPA DGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW L RRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPP APP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Host
E Coli
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
> 98% by SDS-PAGE and HPLC analyses
Molecular Weight
19.1 kDa
Chromosome Location
Chromosome: 19; NC_000019.10 (55364382..55370463, complement). Location: 19q13.3-q13.4
OMIM
147681
3D Structure
ModBase 3D Structure for P20809
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.1 ng perug of
Biological Activity
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is <= 2.0 ng/ml, corresponding to a specific activity of >= 5 x 105 units/mg.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of IL-11 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-11 purchase

MBS691518 is an active protein targeting IL-11. Also known as Human IL-11. Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-11. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interleukin-11 isoform 1
NCBI Official Synonym Full Names
interleukin 11
NCBI Official Symbol
IL11
NCBI Official Synonym Symbols
AGIF; IL-11
UniProt Protein Name
Interleukin-11
UniProt Synonym Protein Names
Adipogenesis inhibitory factor
UniProt Gene Name
IL11
UniProt Synonym Gene Names
IL-11; AGIF
UniProt Entry Name
IL11_HUMAN
NCBI Protein Information
interleukin-11; oprelvekin; adipogenesis inhibitory factor

NCBI Summary for IL-11

The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
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UniProt Comments for IL-11

Function: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.

Subcellular location: Secreted.

Pharmaceutical use: Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.

Sequence similarities: Belongs to the IL-6 superfamily.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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