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Galectin-1 (LGALS1) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691583

Lectins, of either plant or animal ongm, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. Galectin-I (Gal-I) is one of 15 evolutionarily conserved 13-galactoside-binding proteins that display… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Galectin-1 (LGALS1), Active Protein
Full Product Name
Human Galectin-1
Product Gene Name
LGALS1 active protein
Product Synonym Names
Recombinant Human Galectin-1
Sequence
ACGLVASNLN LKPGECLRVR GEVAPDAKSF VLNLGKDSNN LCLHFNPRFN AHGDANTIVC NSKDGGAWGT EQREAVFPFQ PGSVAEVCIT FDQANLTVKL PDGYEFKFPN RLNLEAINYM AADGDFKIKC VAFD
Result by N-terminal sequencing :ACGLVASNL NLKPGE
Host
E Coli
Species Reactivity
Human
Form/Format
lyophilized
Purity/Purification
>98% by SDS-PAGE & Coomassie stain
Preparation and Storage
The lyophilized human Galectin-l, though stable at room temperature, is best stored desiccated below O degree C. Reconstituted human Galectin-I should be stored in working aliquots at -20 degree C . Avoid repeated freeze and thaw cycles!
Molecular Weight
~14 kDa
Chromosome Location
Chromosome: 22; NC_000022.11 (37675606..37679802). Location: 22q13.1
OMIM
150570
3D Structure
ModBase 3D Structure for P09382
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.1 ng per ug of Galectin-1
Biological Activity
Determine by its ability to chemoattract human blood monocytes. Chemotactic activity was observed at a concentration of 2.5 ug/ml with a peak response obatined at 250 ug/ml.
Reconstitution
Human Galectin-I should be reconstituted in water to a concentration of 0.1 mg/mI. This solution can be diluted in water or other buffer solutions or stored at -20 degree C.
Buffer
PBS
Stabilizer
None

Product Categories/Family for LGALS1 active protein

Cytokines & Growth Factors
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

SDS-PAGE of LGALS1 active protein

SDS-PAGE analysis of recombinant human Galectin-1. Sample was loaded in 15% SDS-polyacrylamide gel under reducing condition and stained with Coomassie blue.
Human LGALS1 Active Protein – Cat# MBS691583

Other Notes

Small volumes of LGALS1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LGALS1 purchase

MBS691583 is an active protein targeting LGALS1. Also known as Human Galectin-1. Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for LGALS1. It may not necessarily be applicable to this product.

NCBI GI #
4504981
NCBI GeneID
3956
NCBI Accession #
NP_002296.1
UniProt Primary Accession #
P09382
UniProt Secondary Accession #
Q9UDK5; B2R5E8
UniProt Related Accession #
P09382
GenBank Nucleotide #
NM_002305.3
NCBI Official Full Name
galectin-1
NCBI Official Synonym Full Names
lectin, galactoside-binding, soluble, 1
NCBI Official Symbol
LGALS1
NCBI Official Synonym Symbols
GBP; GAL1
UniProt Protein Name
Galectin-1
UniProt Synonym Protein Names
14 kDa laminin-binding protein; HLBP14; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; Galaptin; HBL; HPL; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; Putative MAPK-activating protein PM12; S-Lac lectin 1
Protein Family
Galectin
UniProt Gene Name
LGALS1
UniProt Synonym Gene Names
Gal-1; HLBP14
UniProt Entry Name
LEG1_HUMAN
NCBI Protein Information
galectin-1; HBL; HPL; gal-1; HLBP14; galaptin; galectin 1; 14 kDa lectin; S-Lac lectin 1; lactose-binding lectin 1; 14 kDa laminin-binding protein; putative MAPK-activating protein PM12; beta-galactoside-binding lectin L-14-I; beta-galactoside-binding protein 14kDa

NCBI Summary for LGALS1

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]

UniProt Comments for LGALS1

Function: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Ref.24 Ref.26 Ref.31

Subunit structure: Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Ref.18 Ref.23 Ref.30 Ref.31

Subcellular location: Secreted › extracellular space › extracellular matrix Ref.24.

Tissue specificity: Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. Ref.4 Ref.26

Sequence similarities: Contains 1 galectin domain.
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Research Articles on LGALS1

1. Gal-1 as a diagnostic biomarker and immunotherapeutic target for LSCC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LGALS1 active protein

 Reference Product  PubMed Publications
 PTPRC active protein  >31 publications with LGALS1 and PTPRC
 CD7 active protein  >20 publications with LGALS1 and CD7
 MYC active protein  >10 publications with LGALS1 and MYC
 TDG active protein  >6 publications with LGALS1 and TDG
 GEMIN4 active protein  >4 publications with LGALS1 and GEMIN4
 MAX active protein  >2 publications with LGALS1 and MAX
 BEX2 active protein  >1 publications with LGALS1 and BEX2
 POU2AF1 active protein  >1 publications with LGALS1 and POU2AF1

Pathways associated with LGALS1 active protein

 Products by Pathway  Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram

Diseases associated with LGALS1 active protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >351 publications with LGALS1 and Neoplasms
 Inflammation Antibodies  >110 publications with LGALS1 and Inflammation
 Disease Models, Animal Antibodies  >65 publications with LGALS1 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >64 publications with LGALS1 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >57 publications with LGALS1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >46 publications with LGALS1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >37 publications with LGALS1 and Breast Neoplasms
 Lung Diseases Antibodies  >29 publications with LGALS1 and Lung Diseases
 Lung Neoplasms Antibodies  >29 publications with LGALS1 and Lung Neoplasms
 Necrosis Antibodies  >27 publications with LGALS1 and Necrosis

Organs/Tissues associated with LGALS1 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >336 publications with LGALS1 and Blood
 Brain Antibodies  >85 publications with LGALS1 and Brain
 Vascular Antibodies  >68 publications with LGALS1 and Vascular
 Muscle Antibodies  >59 publications with LGALS1 and Muscle
 Nerve Antibodies  >56 publications with LGALS1 and Nerve
 Bone Antibodies  >50 publications with LGALS1 and Bone
 Lung Antibodies  >48 publications with LGALS1 and Lung
 Skin Antibodies  >47 publications with LGALS1 and Skin
 Embryonic Tissue Antibodies  >45 publications with LGALS1 and Embryonic Tissue
 Liver Antibodies  >44 publications with LGALS1 and Liver
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