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TPO Rat Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691621

TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl… More details

$305 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TPO, Active Protein
Full Product Name
Rat TPO
Product Gene Name
Product Synonym Names
DDX4; VASA
Sequence
SPVPPACDPR LLNKLLRDSY LLHSRLSQCP DVNPLSIPVL LPAVDF SLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL G QLSGQVRLL LGALQGLLGT QLPPQGRTTA HKDPSALFLS LQQLLRG KVR FLLLVEGPAL CVRRTLPTTA VPSRTSQLLT LNKF
Host
E Coli
Species Reactivity
Rat
Form/Format
Lyophilized
Purity/Purification
> 98% by SDS-PAGE & HPLC analyses
Molecular Weight
34,556 Da
Chromosome Location
Chromosome: 11; NC_005110.3 (85925385..85932532). Location: 11q23
3D Structure
ModBase 3D Structure for P49745
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Determined by its ability to stimulate the proliferation of human MO7e cells. The expected B>ED50 is <= 0.2 ng/ml, corresponding to a specific activity of >= 5 x 106 units/mg.

Product Categories/Family for TPO active protein

ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of TPO active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TPO purchase

MBS691621 is an active protein targeting TPO. Also known as Rat TPO. Reactive in Rat. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TPO. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
thrombopoietin
NCBI Official Synonym Full Names
thrombopoietin
NCBI Official Symbol
Thpo
UniProt Protein Name
Thrombopoietin
Protein Family
UniProt Gene Name
Thpo
UniProt Entry Name
TPO_RAT
NCBI Protein Information
thrombopoietin

NCBI Summary for TPO

lineage-specific cytokine; important for proliferation and development of megakaryocytes and platelets; may be the major regulator of circulating platelets [RGD, Feb 2006]

UniProt Comments for TPO

Function: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

Subcellular location: Secreted.

Domain: Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.

Sequence similarities: Belongs to the EPO/TPO family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with TPO active protein

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