Human AITRL Active Protein – Cat# MBS691626

AITRL Human Active Protein

Name: AITRL Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS691626
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691626

AITRL, a member of the TNF superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. The AITRL gene… More details

$305 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AITRL, Active Protein

Full Product Name

Human AITRL

Product Gene Name

AITRL active protein

Product Synonym Names

Recombinant Human AITRL

Sequence

ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLI YGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE L HVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFI

Host

E Coli

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

> 98% by SDS-PAGE and HPLC analyses

Molecular Weight

14.3 kDa

Chromosome Location

Chromosome: 1; NC_000001.11 (173041220..173050963, complement). Location: 1q23

OMIM

603898

3D Structure

ModBase 3D Structure for Q9UNG2

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 0.1 ng per ug of AITRL

Biological Activity

Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 1.0-10.0 ng/ml. Please Note: Results may vary with PBMC donors.

Product Categories/Family for AITRL active protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of AITRL active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AITRL purchase

MBS691626 is an active protein targeting AITRL. Also known as Human AITRL. Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for AITRL. It may not necessarily be applicable to this product.

NCBI GI #

157419142

NCBI GeneID

8995

NCBI Accession #

NP_005083.2

UniProt Primary Accession #

Q9UNG2

UniProt Secondary Accession #

O95852; Q6ISV1; A9IQG8

UniProt Related Accession #

Q9UNG2

GenBank Nucleotide #

NM_005092.3

NCBI Official Full Name

tumor necrosis factor ligand superfamily member 18

NCBI Official Synonym Full Names

tumor necrosis factor (ligand) superfamily, member 18

NCBI Official Symbol

TNFSF18

NCBI Official Synonym Symbols

TL6; AITRL; GITRL; hGITRL

UniProt Protein Name

Tumor necrosis factor ligand superfamily member 18

UniProt Synonym Protein Names

Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand

Protein Family

Tumor necrosis factor ligand superfamily

UniProt Gene Name

TNFSF18

UniProt Synonym Gene Names

AITRL; GITRL; TL6; AITRL; hGITRL

UniProt Entry Name

TNF18_HUMAN

NCBI Protein Information

tumor necrosis factor ligand superfamily member 18; AITR ligand; GITR ligand; activation-inducible TNF-related ligand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand

NCBI Summary for AITRL

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]

UniProt Comments for AITRL

Function: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Ref.8 Ref.9

Subunit structure: Homodimer

By similarity. Homotrimer. Ref.9

Subcellular location: Cell membrane; Single-pass type II membrane protein Ref.8.

Tissue specificity: Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.

Induction: Up-regulated after stimulation by bacterial lipopolysaccharides (LPS).

Sequence similarities: Belongs to the tumor necrosis factor family.

Caution: It is uncertain whether Met-1 or Met-23 is the initiator.

Sequence caution: The sequence AAH93986.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAI12033.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAQ89227.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAG36082.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence EAW90937.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Research Articles on AITRL

1. Serum GITRL levels were higher in SLE patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AITRL active protein

Reference Product	PubMed Publications
TNFRSF18 active protein	>50 publications with AITRL and TNFRSF18
CD4 active protein	>41 publications with AITRL and CD4
IL2RA active protein	>5 publications with AITRL and IL2RA
ICOSLG active protein	>3 publications with AITRL and ICOSLG
TNFRSF4 active protein	>1 publications with AITRL and TNFRSF4

Pathways associated with AITRL active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with AITRL active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>96 publications with AITRL and Necrosis
Neoplasms, Experimental Antibodies	>9 publications with AITRL and Neoplasms, Experimental
Nervous System Diseases Antibodies	>4 publications with AITRL and Nervous System Diseases
Colitis Antibodies	>2 publications with AITRL and Colitis
Carcinoma, Hepatocellular Antibodies	>2 publications with AITRL and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>2 publications with AITRL and Liver Neoplasms
Brain Neoplasms Antibodies	>1 publications with AITRL and Brain Neoplasms
Spinal Cord Diseases Antibodies	>1 publications with AITRL and Spinal Cord Diseases
Pleural Effusion Antibodies	>1 publications with AITRL and Pleural Effusion
Thrombocytopenia Antibodies	>1 publications with AITRL and Thrombocytopenia

Organs/Tissues associated with AITRL active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with AITRL and Brain
Vascular Antibodies	>4 publications with AITRL and Vascular
Muscle Antibodies	>3 publications with AITRL and Muscle
Mixed Antibodies	>2 publications with AITRL and Mixed